Document Detail


Clinical pharmacokinetics of furosemide in children with nephrotic syndrome.
MedLine Citation:
PMID:  6668097     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pharmacokinetic disposition of furosemide has been investigated in seven children with nephrotic syndrome and in eight control children. Furosemide in plasma was analyzed by spectrofluorometry. After a single intravenous dose of furosemide (1 mg/kg body wt.) the nephrotic children showed lower initial plasma concentrations because of the larger volume of distribution. The mean half-life of furosemide in nephrotic children (38.5 +/- 7.8 min) was significantly longer than in the control group (28.0 +/- 7.7 min). The two groups did not differ in the body clearance of total furosemide. The average serum clearance was 4.95 +/- 1.7 ml/min/kg body wt. in the control group and 5.10 +/- 1.4 ml/min/kg body wt. in the nephrotic children. There was a significant reduction in urine sodium and distribution volume, whereas potassium excretion remained unchanged.
Authors:
G González-Martín; I Bravo; N Ibarra; A Arancibia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology, therapy, and toxicology     Volume:  21     ISSN:  0174-4879     ISO Abbreviation:  Int J Clin Pharmacol Ther Toxicol     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-04-16     Completed Date:  1984-04-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8003415     Medline TA:  Int J Clin Pharmacol Ther Toxicol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  598-601     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Child, Preschool
Female
Furosemide / blood,  metabolism*,  therapeutic use
Humans
Injections, Intravenous
Kinetics
Male
Nephrotic Syndrome / drug therapy*,  metabolism
Potassium / urine
Sodium / urine
Time Factors
Chemical
Reg. No./Substance:
54-31-9/Furosemide; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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