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Clinical pharmacokinetics of epirubicin: the importance of liver biochemistry tests.
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MedLine Citation:
PMID:  1419619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of liver biochemistry tests on epirubicin pharmacokinetics has been investigated in 52 women with advanced breast cancer, 27 of whom had radiologically proven liver metastases. Patients received epirubicin 12.5-120 mg m-2 given as an i.v. bolus. Epirubicin levels were measured by HPLC following the first cycle of treatment. Epirubicin elimination, expressed as clearance (dose/AUC), in the 22 patients with normal AST and bilirubin was compared with that of 30 patients with a raised AST +/- raised bilirubin. Epirubicin clearance was significantly reduced in the patients with a raised AST, whether their serum bilirubin was normal (22 patients) or elevated (eight patients). In the 30 patients with a raised AST +/- raised bilirubin, epirubicin clearance correlated strongly with the level of AST (r = -0.72) but not with serum bilirubin, alkaline phosphatase, albumin or creatinine. Using a multiple regression analysis, AST was the only one of these biochemical variables predictive of epirubicin clearance (r2 = 0.47, P = 0.0006). We conclude that a raised serum AST is a more sensitive and reliable measure of abnormal epirubicin pharmacokinetics than increased bilirubin. These findings have implications for anthracycline treatment in patients with abnormal liver biochemistry.
Authors:
C J Twelves; N A Dobbs; Y Michael; L A Summers; W Gregory; P G Harper; R D Rubens; M A Richards
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of cancer     Volume:  66     ISSN:  0007-0920     ISO Abbreviation:  Br. J. Cancer     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-12-01     Completed Date:  1992-12-01     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  0370635     Medline TA:  Br J Cancer     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  765-9     Citation Subset:  IM    
Affiliation:
Imperial Cancer Research Fund Clinical Oncology Unit, United Medical School, Guy's Hospital, London.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aspartate Aminotransferases / blood*
Bilirubin / blood
Breast Neoplasms / metabolism*
Epirubicin / pharmacokinetics*
Female
Humans
Liver / metabolism*
Liver Function Tests
Liver Neoplasms / metabolism*,  secondary*
Middle Aged
Chemical
Reg. No./Substance:
56420-45-2/Epirubicin; 635-65-4/Bilirubin; EC 2.6.1.1/Aspartate Aminotransferases
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Br J Cancer
ISSN: 0007-0920
ISSN: 1532-1827
Article Information
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Print publication date: Month: 10 Year: 1992
Volume: 66 Issue: 4
First Page: 765 Last Page: 769
ID: 1977407
PubMed Id: 1419619

Clinical pharmacokinetics of epirubicin: the importance of liver biochemistry tests.
C. J. Twelves
N. A. Dobbs
Y. Michael
L. A. Summers
W. Gregory
P. G. Harper
R. D. Rubens
M. A. Richards
Imperial Cancer Research Fund Clinical Oncology Unit, United Medical School, Guy's Hospital, London.



Article Categories:
  • Research Article


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