Document Detail

Clinical performance of the levonorgestrel intrauterine system in routine use by the UK Family Planning and Reproductive Health Research Network: 5-year report.
MedLine Citation:
PMID:  12396776     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: This study was undertaken to determine the performance of the levonorgestrel intrauterine system (LNG IUS) in British women in routine clinical use. DESIGN: Doctors working in general practice and at family planning clinics throughout the UK who collaborate in the UK Family Planning and Reproductive Health Research Network were responsible for the fitting of 678 LNG IUSs. RESULTS: Gross cumulative event rates at 5 years per 100 women were pregnancy 1.0, expulsion 5.9, removal for bleeding problems 16.7, removal for pain 4.3, and removal for pelvic inflammatory disease (PID) 1.2. Removals were also required for side effects that may be due to absorbed levonorgestrel. Positive effects include effective contraception and considerably reduced quantity of bleeding for most participants. CONCLUSIONS: A need was identified to counsel women about the early bleeding problems including the possibility of oligomenorrhoea or amenorrhoea. This is considered to be very important as it will help women to persevere so that they can enjoy the longer-term benefits.
Michael Cox; John Tripp; Sarah Blacksell
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Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase III; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journal of family planning and reproductive health care / Faculty of Family Planning & Reproductive Health Care, Royal College of Obstetricians & Gynaecologists     Volume:  28     ISSN:  1471-1893     ISO Abbreviation:  J Fam Plann Reprod Health Care     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-10-24     Completed Date:  2002-11-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101087687     Medline TA:  J Fam Plann Reprod Health Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  73-7     Citation Subset:  IM    
Consultant Obstetrician and Gynaecologist (Retired), Nuneaton, UK.
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MeSH Terms
Device Removal / statistics & numerical data
Great Britain / epidemiology
Intrauterine Devices, Medicated* / adverse effects
Life Tables
Pelvic Inflammatory Disease / epidemiology,  etiology
Pregnancy Rate
Progesterone Congeners*
Uterine Hemorrhage / epidemiology,  etiology
Reg. No./Substance:
0/Progesterone Congeners; 797-63-7/Levonorgestrel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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