Document Detail

Clinical, pathological and toxicological findings of a iatrogenic selenium toxicosis case in feeder pigs.
MedLine Citation:
PMID:  16901278     Owner:  NLM     Status:  MEDLINE    
Histopathological and toxicological analyses confirmed a clinical diagnosis of selenium (Se) intoxication in pigs from a farm in Spain. After an initial episode of diarrhoea, animals presented both dermatological and neurological signs; the most obvious sign was a marked hind limb paresis. Cutaneous lesions consisted on diffuse alopecia, multifocal skin necrosis and coronary band necrosis of the hooves. Central nervous system lesions involved the cervical and lumbar intumescences of the spinal cord and consisted of a severe, bilateral symmetrical poliomyelomalacia of the ventral horns; pons and medulla oblongata also presented lesions of polioencephalomalacia. Analyses of feed and sera from clinically affected pigs revealed a marked increase in Se concentration. Clinical investigations indicated that a failure in Se dosage in feed was the cause of the toxicosis.
A Casteignau; A Fontán; A Morillo; J A Oliveros; J Segalés
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of veterinary medicine. A, Physiology, pathology, clinical medicine     Volume:  53     ISSN:  0931-184X     ISO Abbreviation:  J Vet Med A Physiol Pathol Clin Med     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-11     Completed Date:  2006-10-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100955112     Medline TA:  J Vet Med A Physiol Pathol Clin Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  323-6     Citation Subset:  IM    
Unité Pédagogique d'Histologie et Anatomie Pathologique, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France.
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MeSH Terms
Alopecia / chemically induced,  veterinary
Animal Feed / analysis*
Food Contamination / analysis*
Hoof and Claw / pathology
Lameness, Animal / chemically induced,  pathology
Selenium / poisoning*
Spinal Cord / pathology
Swine Diseases / chemically induced*,  pathology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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