Document Detail


Clinical and pathological implications of concurrent autoimmune thyroid disorders and papillary thyroid cancer.
MedLine Citation:
PMID:  21403889     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Cooccurrences of chronic lymphocytic thyroiditis (CLT) and thyroid cancer (DTC) have been repeatedly reported. Both CLT and DTC, mainly papillary thyroid carcinoma (PTC), share some epidemiological and molecular features. In fact, thyroid lymphocytic inflammatory reaction has been observed in association with PTC at variable frequency, although the precise relationship between the two diseases is still debated. It also remains a matter of debate whether the association with a CLT or even an autoimmune disorder could influence the prognosis of PTC. A better understanding about clinical implications of autoimmunity in concurrent thyroid cancer could raise new insights of thyroid cancer immunotherapy. In addition, elucidating the molecular mechanisms involved in autoimmune disease and concurrent cancer allowed us to identify new therapeutic strategies against thyroid cancer. The objective of this article was to review recent literature on the association of these disorders and its potential significance.
Authors:
L L Cunha; R C Ferreira; M A Marcello; J Vassallo; L S Ward
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Publication Detail:
Type:  Journal Article     Date:  2011-02-17
Journal Detail:
Title:  Journal of thyroid research     Volume:  2011     ISSN:  2042-0072     ISO Abbreviation:  J Thyroid Res     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-15     Completed Date:  2011-07-14     Revised Date:  2011-07-26    
Medline Journal Info:
Nlm Unique ID:  101536655     Medline TA:  J Thyroid Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  387062     Citation Subset:  -    
Affiliation:
Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences, University of Campinas (FCM-Unicamp), 126 Tessalia Vieira de Camargo St., Cidade Universitária, Barão Geraldo, Campinas, 13083-970 São Paulo, SP, Brazil.
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