| Clinical and pathological aspects of experimental oleander (Nerium oleander) toxicosis in sheep. | |
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MedLine Citation:
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PMID: 15563108 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dried Nerium oleander leaves at single lethal dose of 110 mg/kg body weight were administered orally to six native male sheep. Clinical signs of toxicosis in sheep began to appear about 30 min after receiving the oleander and included decrease of the heart rate followed by cardiac pauses and tachyarrhythmias; ruminal atony, mild to moderate tympany, abdominal pain, polyuria and polakiuria. Electrocardiography revealed bradycardia, atrio-ventricular blocks, depression of S-T segments, ventricular premature beats and tachycardia, and ventricular fibrillation. Five sheep died within 4-12 h and one survived. At necropsy there were varying degrees of haemorrhages in different organs and gastroenteritis. Histopathological examination of tissue sections revealed myocardial degeneration and necrosis, degeneration and focal necrosis of hepatocytes, necrosis of tubular epithelium in kidneys, oedema in the lungs, and ischemic changes in the cerebrum. |
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Authors:
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M R Aslani; A R Movassaghi; M Mohri; A Abbasian; M Zarehpour |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Veterinary research communications Volume: 28 ISSN: 0165-7380 ISO Abbreviation: Vet. Res. Commun. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-11-25 Completed Date: 2005-01-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8100520 Medline TA: Vet Res Commun Country: Netherlands |
Other Details:
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Languages: eng Pagination: 609-16 Citation Subset: IM |
Affiliation:
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Department of Clinical Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, P.O. Box 91775-1793, Mashhad, Iran. mraslani@ferdowsi.um.ac.ir |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Electrocardiography / veterinary Hepatocytes / pathology Histocytochemistry / veterinary Kidney Tubules / pathology Lung / pathology Male Myocardium / pathology Nerium / metabolism, toxicity* Plant Leaves / metabolism, toxicity Plants, Toxic / metabolism, toxicity* Sheep Sheep Diseases / etiology*, metabolism, pathology Telencephalon / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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