Document Detail


Clinical and pathologic tumor size in renal cell carcinoma; difference, correlation, and analysis of the influencing factors.
MedLine Citation:
PMID:  12100917     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To investigate the relation between the clinical and pathologic size and to identify the factors that affect this relationship. The clinical size of the tumor is essential for choosing the appropriate treatment in renal cell carcinoma. The pathologic size, on the other hand, is an important prognostic indicator. METHODS: We reviewed the charts of 291 open nephrectomy patients treated for nonmetastatic renal cell carcinoma. Clinical size was defined as the largest diameter on contrast-enhanced computed tomography. Pathologic size was defined as the largest diameter on pathologic examination. The clinical and pathologic sizes were compared, and their correlation was analyzed. The effect of various clinical and pathologic factors on the percentage of the size difference (%Delta(size)) was analyzed. RESULTS: The mean clinical and pathologic size was 5.4 +/- 3.2 and 5.3 +/- 3.3 cm, respectively. The difference was not significant (P = 0.1679). The clinical and pathologic size also correlated highly (r = 0.9540; P <0.0001). The estimated blood loss, local tumor extension, and cell type had significant influence on the %Delta(size) (P = 0.0018, 0.0415, and 0.0079, respectively). Additionally, in approximately one half of the patients with the greatest size difference, features such as cystic masses, hemorrhage, pyelonephritis, localization near or invasion of the collecting system, cysts or dilated calices adjacent to the tumor, and multiple cysts within the kidney were present, which were identified as factors that might have influenced the accuracy of the clinical size. CONCLUSIONS: The overall accuracy of the clinical size and its correlation with the pathologic size was acceptable. However, the presence of the above-mentioned factors should be taken into consideration during the interpretation of clinical tumor size.
Authors:
Ozgur Yaycioglu; Matthew P Rutman; Mamtha Balasubramaniam; Kenneth M Peters; Jose A Gonzalez
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Urology     Volume:  60     ISSN:  1527-9995     ISO Abbreviation:  Urology     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-08     Completed Date:  2002-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  33-8     Citation Subset:  IM    
Affiliation:
Department of Urology, William Beaumont Hospital, Royal Oak, Michigan, USA.
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Renal Cell / pathology*,  radiography*,  surgery
Female
Humans
Kidney / pathology*,  radiography*
Kidney Diseases / pathology,  radiography
Kidney Neoplasms / pathology*,  radiography*,  surgery
Male
Middle Aged
Neoplasm Staging
Nephrectomy
Prognosis
Retrospective Studies
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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