Document Detail

Clinical and pathologic cutaneous manifestations of malignant histiocytosis.
MedLine Citation:
PMID:  6847214     Owner:  NLM     Status:  MEDLINE    
The clinical and pathologic changes in the skin of five patients with malignant histiocytosis were studied. The clinical signs included papules, nodules, noduloulcers and purpura. The histopathologic changes included exocytosis of inflammatory cells, infiltration of the papillary and reticular dermis with neoplastic histiocytes, and periadnexal and perivascular infiltrates. Phagocytosis of RBCs and nuclear debris by atypical histiocytes was seen in two cases. In one case, the skin lesions were the only initial manifestation of the disease. Skin involvement occurs in about 10% to 15% of all cases of malignant histiocytosis. Hence, it is important to include malignant histiocytosis in the differential diagnosis of patients with such skin lesions, especially when clinical symptoms may be suggestive of this disease.
N E Morgan; D Fretzin; D Variakojis; W A Caro
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of dermatology     Volume:  119     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-06-10     Completed Date:  1983-06-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  367-72     Citation Subset:  AIM; IM    
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MeSH Terms
Diagnosis, Differential
Histiocytes / pathology
Lymphatic Diseases / diagnosis*,  pathology
Retrospective Studies
Skin / pathology
Skin Diseases / diagnosis,  pathology

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