Document Detail

Clinical and pathobiologic considerations in the evaluation of markers of myocardial ischemia.
MedLine Citation:
PMID:  12213985     Owner:  NLM     Status:  MEDLINE    
There is a need for blood-based analytic techniques that allow for the detection of patients either with reversible myocardial ischemia or who are at risk for myocardial ischemia. However, given the diverse etiologies of unstable angina and the complex interactions among various cell types, the term "marker for ischemia" should be used with caution (if at all). Unless we find a protein that is released across the diverse pathologic triggers associated with the various stages of progression of atherosclerosis and cellular ischemia, we will be forced to consider a spectrum of proteins (and analytic assays) that are situationally specific. The choice of an appropriate gold standard as we investigate the clinical application of these assays will be one of the most difficult and most important decisions in these studies. It will be critical that conclusions of usefulness in one setting of ischemic heart disease not be generalized in the absence of clinical trials supporting that contention.
J E Adams
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cardiovascular toxicology     Volume:  1     ISSN:  1530-7905     ISO Abbreviation:  Cardiovasc. Toxicol.     Publication Date:  2001  
Date Detail:
Created Date:  2002-09-05     Completed Date:  2002-10-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  101135818     Medline TA:  Cardiovasc Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  135-9     Citation Subset:  IM    
Jewish Hospital Heart and Lung Institute, Louisville KY 40202, USA.
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MeSH Terms
Biological Markers / analysis*
Myocardial Ischemia / diagnosis*,  pathology*,  therapy
Reg. No./Substance:
0/Biological Markers

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