Document Detail

Clinical parameters of adolescent Hispanic male hypertensive subjects: a new subject?
MedLine Citation:
PMID:  3668589     Owner:  NLM     Status:  MEDLINE    
We have previously reported an increased prevalence of elevated blood pressure in Hispanic adolescent males. The pressure elevation did not correlate with weight. In this study, we evaluated the response to antihypertensive therapy of eight adolescent Hispanic males found to have elevated pressure during high school screening. All patients were placed on placebo tablets b.i.d. for 2 weeks with weekly blood pressure readings. Those with persistently elevated pressures (at or above the 95th percentile) underwent laboratory testing, exercise testing, and echocardiography. An age-matched group of Hispanic adolescents with blood pressure recording below the 90th percentile were also exercised. Patients were then placed on 0.1 mg clonidine b.i.d. for 12 weeks. Pretherapy exercise testing demonstrated an abnormal systolic hypertensive response (mean 193 +/- 43 mmHg) that improved after therapy (mean 167 +/- 28 mmHg). Echocardiographic data were normal. All patients had elevated levels of VLDL and triglycerides. Five patients also had HDL levels below the 50th percentile for age and sex. We conclude that this population is similar to other hypertensive adolescent populations in exercise response pre- and posttherapy with clonidine, but they demonstrated a unique clinical feature in the elevation of the VLDL and triglyceride lipoprotein fractions.
I L Pina; E V Smith; K M Kessler; R J Myerburg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of clinical hypertension     Volume:  3     ISSN:  0748-450X     ISO Abbreviation:  J Clin Hypertens     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-11-25     Completed Date:  1987-11-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8510461     Medline TA:  J Clin Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  262-70     Citation Subset:  IM    
Division of Cardiology, University of Miami School of Medicine, Florida.
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MeSH Terms
Clonidine / therapeutic use
Exercise Test
Hispanic Americans*
Hypertension / drug therapy,  ethnology*
Lipids / blood
Grant Support
Reg. No./Substance:
0/Lipids; 0/Placebos; 4205-90-7/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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