| Clinical outcomes with extended or continuous versus short-term intravenous infusion of carbapenems and piperacillin/tazobactam: a systematic review and meta-analysis. | |
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MedLine Citation:
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PMID: 23074314 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We sought to study whether the better pharmacokinetic and pharmacodynamic (PK/PD) properties of carbapenems and piperacillin/tazobactam, when the duration of infusion is longer, were associated with lower mortality. PubMed and Scopus were searched for studies reporting on patients treated with extended (≥ 3h) or continuous (24h) versus short-term duration (20-60 min) infusions of carbapenems or piperacillin/tazobactam. Fourteen studies were included (1229 patients). Mortality was lower among patients receiving extended or continuous infusion of carbapenems or piperacillin/tazobactam compared to those receiving short-term, (RR 0.59, 95% CI: 0.41-0.83). Patients with pneumonia who received extended or continuous infusion had lower mortality than those receiving short-term infusion [0.50, 0.26-0.96). Data for other specific infections was not available. The available evidence from mainly non-randomized studies suggests that extended or continuous infusion of carbapenems or piperacillin/tazobactam was associated with lower mortality. Well designed RCTs are warranted to confirm these findings, before such approaches become widely used. |
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Authors:
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Matthew E Falagas; Giannoula S Tansarli; Kazuro Ikawa; Konstantinos Z Vardakas |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-16 |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: - ISSN: 1537-6591 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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