Document Detail


Clinical outcomes of vitamin D deficiency and supplementation in cancer patients.
MedLine Citation:
PMID:  24032365     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Results of recent studies suggest that circulating levels of vitamin D may play an important role in cancer-specific outcomes. The present systematic review was undertaken to determine the prevalence of vitamin D deficiency (<25 nmol/L) and insufficiency (25-50 nmol/L) in cancer patients and to evaluate the association between circulating calcidiol (the indicator of vitamin D status) and clinical outcomes. A systematic search of original, peer-reviewed studies on calcidiol at cancer diagnosis, and throughout treatment and survival, was conducted yielding 4,706 studies. A total of 37 studies met the inclusion criteria for this review. Reported mean blood calcidiol levels ranged from 24.7 to 87.4 nmol/L, with up to 31% of patients identified as deficient and 67% as insufficient. The efficacy of cholecalciferol supplementation for raising the concentration of circulating calcidiol is unclear; standard supplement regimens of <1,000 IU D3 /day may not be sufficient to maintain adequate concentrations or prevent decreasing calcidiol. Dose-response studies linking vitamin D status to musculoskeletal and survival outcomes in cancer patients are lacking.
Authors:
Laisa Teleni; Jacqueline Baker; Bogda Koczwara; Michael G Kimlin; Euan Walpole; Kathy Tsai; Elizabeth A Isenring
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Publication Detail:
Type:  Journal Article     Date:  2013-08-15
Journal Detail:
Title:  Nutrition reviews     Volume:  71     ISSN:  1753-4887     ISO Abbreviation:  Nutr. Rev.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-09-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376405     Medline TA:  Nutr Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  611-21     Citation Subset:  IM    
Copyright Information:
© 2013 International Life Sciences Institute.
Affiliation:
School of Public Health and Social Work, Queensland University of Technology, Brisbane, Queensland, Australia; Department of Nutrition and Dietetics, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
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