| Clinical outcomes for sirolimus-eluting stent implantation and vascular brachytherapy for the treatment of in-stent restenosis. | |
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MedLine Citation:
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PMID: 15224289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to compare the mid-term clinical outcome of sirolimus-eluting stent (SES) implantation and vascular brachytherapy (VBT) for in-stent restenosis (ISR). We assessed the 9-month occurrence of major adverse cardiac events (MACE) in 44 consecutive patients with ISR treated with SES implantation and 43 consecutive patients treated with VBT in the period immediately prior. Baseline clinical and angiographic characteristics of the two groups were similar. During follow-up, three patients (7%) died in the VBT group and none in the SES group. The incidence of myocardial infarction was 2.3% in both groups. Target lesion revascularization was performed in 11.6% of the VBT patients and 16.3% of the SES patients (P = NS). The 9-month MACE-free survival was similar in both groups (79.1% VBT vs. 81.5% SES; P = 0.8 by log rank). The result of this nonrandomized study suggests that sirolimus-eluting stent implantation is at least as effective as vascular brachytherapy in the treatment of in-stent restenosis. |
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Authors:
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Francesco Saia; Pedro A Lemos; Angela Hoye; Georgios Sianos; Chourmouzios A Arampatzis; Pim J de Feyter; Willem J van der Giessen; Pieter C Smits; Ron T van Domburg; Patrick W Serruys |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions Volume: 62 ISSN: 1522-1946 ISO Abbreviation: Catheter Cardiovasc Interv Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-06-29 Completed Date: 2004-11-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100884139 Medline TA: Catheter Cardiovasc Interv Country: United States |
Other Details:
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Languages: eng Pagination: 283-8 Citation Subset: IM |
Copyright Information:
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Copyright 2004 Wiley-Liss, Inc. |
Affiliation:
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Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brachytherapy* Chi-Square Distribution Coronary Restenosis / drug therapy*, radiotherapy* Female Humans Immunosuppressive Agents / administration & dosage* Male Middle Aged Sirolimus / administration & dosage* Stents* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 53123-88-9/Sirolimus |
| Comments/Corrections | |
Comment In:
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Catheter Cardiovasc Interv. 2004 Jul;62(3):289
[PMID:
15224290
]
Catheter Cardiovasc Interv. 2004 Jul;62(3):290-1 [PMID: 15224291 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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