Document Detail

Clinical outcomes for sirolimus-eluting stent implantation and vascular brachytherapy for the treatment of in-stent restenosis.
MedLine Citation:
PMID:  15224289     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to compare the mid-term clinical outcome of sirolimus-eluting stent (SES) implantation and vascular brachytherapy (VBT) for in-stent restenosis (ISR). We assessed the 9-month occurrence of major adverse cardiac events (MACE) in 44 consecutive patients with ISR treated with SES implantation and 43 consecutive patients treated with VBT in the period immediately prior. Baseline clinical and angiographic characteristics of the two groups were similar. During follow-up, three patients (7%) died in the VBT group and none in the SES group. The incidence of myocardial infarction was 2.3% in both groups. Target lesion revascularization was performed in 11.6% of the VBT patients and 16.3% of the SES patients (P = NS). The 9-month MACE-free survival was similar in both groups (79.1% VBT vs. 81.5% SES; P = 0.8 by log rank). The result of this nonrandomized study suggests that sirolimus-eluting stent implantation is at least as effective as vascular brachytherapy in the treatment of in-stent restenosis.
Francesco Saia; Pedro A Lemos; Angela Hoye; Georgios Sianos; Chourmouzios A Arampatzis; Pim J de Feyter; Willem J van der Giessen; Pieter C Smits; Ron T van Domburg; Patrick W Serruys
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  62     ISSN:  1522-1946     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-29     Completed Date:  2004-11-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  283-8     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Wiley-Liss, Inc.
Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands.
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MeSH Terms
Chi-Square Distribution
Coronary Restenosis / drug therapy*,  radiotherapy*
Immunosuppressive Agents / administration & dosage*
Middle Aged
Sirolimus / administration & dosage*
Treatment Outcome
Reg. No./Substance:
0/Immunosuppressive Agents; 53123-88-9/Sirolimus
Comment In:
Catheter Cardiovasc Interv. 2004 Jul;62(3):289   [PMID:  15224290 ]
Catheter Cardiovasc Interv. 2004 Jul;62(3):290-1   [PMID:  15224291 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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