Document Detail


Clinical outcomes of patients with biopsy-proven lupus nephritis in NUH.
MedLine Citation:
PMID:  12693764     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To review the clinical outcomes of Systemic Lupus Erythematosus (SLE) patients with biopsy-proven lupus nephritis with regards to the histological features and treatment. METHOD: Patients (1) with SLE, (2) had renal biopsy in NUH for lupus nephritis, and (3) on follow-up from the period of January 1998 to April 2001, were reviewed. RESULT: Fifty patients were reviewed with female to male ratio of 4:1. Mean age was 35.4 years. Sixty-eight percent had renal involvement at diagnosis of SLE. At least 50% had other major organ systems involvement. Forty-two patients had WHO Class IV lupus nephritis. Biopsy showed crescents in 17 patients, microangiopathy in 19, and vasculitis in two patients. All patients received prednisolone. Forty-one had IV cyclophosphamide, two had oral cyclophosphamide and seven had cyclosporin A. Azathioprine was used in 41 patients, pulse methylprednisolone in eight, IVIG in four, plasma exchange in three and mycophenolate in two patients. OUTCOME: Forty-four percent were in complete remission, 26% in partial remission, 34% had relapsed nephritis, 4% had chronic renal failure and 12% progressed to ESRD. There were five deaths. CONCLUSION: Renal involvement in SLE occurs early in the disease and is associated with other organ systems involvement. Only 44% were in complete remission. Thirty-four percent had relapsed. Renal survival was 88% in this cohort.
Authors:
H C Gan; K Hyoon; K Y Fong
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Singapore medical journal     Volume:  43     ISSN:  0037-5675     ISO Abbreviation:  Singapore Med J     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-04-15     Completed Date:  2003-06-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404516     Medline TA:  Singapore Med J     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  614-6     Citation Subset:  IM    
Affiliation:
Department of Medicine, National University Hospital, Lower Kent Ridge Road, Singapore 119074. ganhwachau@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Biopsy
Female
Follow-Up Studies
Humans
Immunosuppressive Agents / therapeutic use
Kidney / drug effects,  pathology*
Kidney Failure, Chronic / drug therapy,  mortality,  pathology
Lupus Nephritis / drug therapy,  mortality,  pathology*
Male
Middle Aged
Survival Analysis
Treatment Outcome
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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