| Clinical outcomes of ovulation induction with metformin, clomiphene citrate and human menopausal gonadotrophin in polycystic ovary syndrome. | |
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MedLine Citation:
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PMID: 20925997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This pilot study evaluated the effects of coadministration of metformin with clomiphene citrate (CC) and human menopausal gonadotrophin (HMG) in women with CC-resistant polycystic ovary syndrome (PCOS). Sixty women with PCOS were randomly assigned to receive 3 months' treatment with metformin or placebo together with CC and HMG. Transvaginal ultrasound was used to monitor follicular development and ovulation was induced by human chorionic gonadotrophin (HCG). The number of dominant follicles, the oestradiol level on the day HCG was given and the amount of HMG required were significantly lower in the metformin group than in the placebo group, whereas the mono-ovulatory rate and pregnancy rate in the third cycle were significantly higher. The cumulative pregnancy rate in the metformin group (43.3%) was higher than in the placebo group (20.0%), but this difference did not reach statistical significance. In conclusion, coadministration of metformin with CC and HMG reduced the amount of HMG required and increased the mono-ovulatory rate and pregnancy rate. |
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Authors:
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J Cheng; J Lv; C Y Li; Y Xue; Z Huang; W Zheng |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The Journal of international medical research Volume: 38 ISSN: 0300-0605 ISO Abbreviation: J. Int. Med. Res. Publication Date: 2010 Jul-Aug |
Date Detail:
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Created Date: 2010-10-07 Completed Date: 2010-12-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346411 Medline TA: J Int Med Res Country: England |
Other Details:
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Languages: eng Pagination: 1250-8 Citation Subset: IM |
Affiliation:
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Department of Gynaecology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Clomiphene / pharmacology, therapeutic use* Drug Resistance / drug effects Female Fertility Agents, Female / therapeutic use* Humans Menotropins / pharmacology, therapeutic use* Metformin / pharmacology, therapeutic use* Ovulation Induction / methods* Polycystic Ovary Syndrome / drug therapy* Pregnancy Pregnancy Outcome Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Fertility Agents, Female; 61489-71-2/Menotropins; 657-24-9/Metformin; 911-45-5/Clomiphene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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