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Clinical outcomes of occupational exposure to n,n-dimethylformamide: perspectives from experimental toxicology.
MedLine Citation:
PMID:  22953193     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
N,N-Dimethylformamide (DMF) is globally used as an organic solvent in the production of synthetic leather and resins because of its low volatility, making it an attractive industrial material. Despite its excellent property as a chemical solvent, utilization of DMF is somewhat controversial nowadays due to its hazardous effects on exposed workers in work places. Many toxification cases are being reported globally and the number of cases of liver damage is still increasing in developing countries. On account of this, a series of epidemiologic surveys are being conducted to understand the degrees of liver damage caused by DMF exposure. Furthermore, many investigations have been performed to clarify the mechanism of DMF-induced liver toxicity using both human and experimental animal models. This review summarizes the current occupational cases reported on liver damage from workers exposed to DMF in industrial work places and the research results that account for DMF-induced liver failure and possible carcinogenesis. The findings reviewed here show the synergistic toxicity of DMF exposure with other toxicants, which might occur through complicated but distinct mechanisms, which may extend our knowledge for establishing risk assessments of DMF exposure in industrial work places.
Authors:
Tae Hyun Kim; Sang Geon Kim
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Publication Detail:
Type:  Journal Article     Date:  2011-06-30
Journal Detail:
Title:  Safety and health at work     Volume:  2     ISSN:  2093-7997     ISO Abbreviation:  Saf Health Work     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2012-09-06     Completed Date:  2012-09-06     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101542940     Medline TA:  Saf Health Work     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  97-104     Citation Subset:  -    
Affiliation:
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea.
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