| Clinical outcomes of exercise-induced pulmonary hypertension in subjects with preserved left ventricular ejection fraction: implication of an increase in left ventricular filling pressure during exercise. | |
| | |
MedLine Citation:
|
PMID: 21653218 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Objective To investigate clinical outcomes of exercise-induced pulmonary hypertension (PH) and implications of an increase in left ventricular (LV) filling pressure during exercise in subjects with preserved LV ejection fraction. Design Longitudinal follow-up study. Setting Subjects who were referred for diastolic stress echocardiography. Patients and methods The ratio of transmitral and annular velocities (E/Ea) and pulmonary artery systolic pressure (PASP) at rest and during exercise were measured in 498 subjects (57±11 years; 201 male). Exercise-induced PH was defined as present if PASP ≥50 mm Hg at 50 W of exercise, and an increase in LV filling pressure during exercise was present if E/Ea ≥15 at 50 W. Main outcome measures A combination of major cardiovascular events and any cause of death. Results During a median follow-up of 41 months, there were 14 hospitalisations and four deaths. Subjects with exercise-induced PH had significantly worse clinical outcomes than those without (p=0.014). Subjects with exercise-induced PH associated with an increase in E/Ea during exercise had significantly worse outcomes than other groups (p<0.001). However, prognosis was similar between subjects with exercise-induced PH without an increase in E/Ea and those without exercise-induced PH. In subjects with exercise-induced PH, E/Ea at 50 W was an independent predictor of adverse outcomes (HR 1.37; 95% CI 1.02 to 1.83; p=0.036). Conclusions Exercise-induced PH provides prognostic information in subjects with preserved LV ejection fraction. The excess risk of exercise-induced PH is restricted to subjects with an increase in estimated LV filling pressure during exercise. |
| | |
Authors:
|
Chi Young Shim; Sung-Ai Kim; Donghoon Choi; Woo-In Yang; Jin-Mi Kim; Sun-Ha Moon; Hyun-Jin Lee; Sungha Park; Eui-Young Choi; Namsik Chung; Jong-Won Ha |
Related Documents
:
|
976258 - Prolonged exercise in prepubertal boys. ii. changes in plasma volume and in some blood ... 16960848 - Current in vivo wear of metal-on-metal bearings assessed by exercise-related rise in pl... 1436528 - Diagnosis of familial hypokalemic periodic paralysis: role of the potassium exercise test. 21131858 - Late cardiovascular drift observable during ultraendurance exercise. 12914828 - Exercise counselling by family physicians in canada. 7904738 - Rehabilitation of the foot and ankle. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-7 |
Journal Detail:
|
Title: Heart (British Cardiac Society) Volume: - ISSN: 1468-201X ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-9 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9602087 Medline TA: Heart Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Gender differences in the utilisation of surgery for congenital heart disease in India.
Next Document: Impact of left ventricular longitudinal diastolic functional reserve on clinical outcome in patients...