| Clinical outcomes of critical illness polyneuropathy. | |
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MedLine Citation:
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PMID: 11898892 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is often difficult to isolate the origin of acute weakness in the critically ill population because of multiple etiologies. Aminoglycosides, corticosteroids, and neuromuscular blockers frequently are implicated as the source of acute weakness. Recently, critical illness polyneuropathy (CIP), a syndrome of unknown etiology, was added to the differential diagnosis. The frequency of CIP is approximately 70% in patients with sepsis. Early studies of CIP, which were mostly retrospective, underestimated its frequency due to the complexity of the diagnosis and unfamiliarity with the syndrome. Prospective studies have explored the causality and clinical outcomes of CIP Clinical outcomes of patients with CIP include difficulty weaning from mechanical ventilation, increased length of stay, prolonged recovery, and an overall mortality rate of 26-71%. The association of CIP with sepsis, multiorgan failure, and drugs is still unclear. |
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Authors:
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Sandra L Kane; Joseph F Dasta |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Pharmacotherapy Volume: 22 ISSN: 0277-0008 ISO Abbreviation: Pharmacotherapy Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-03-18 Completed Date: 2002-09-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8111305 Medline TA: Pharmacotherapy Country: United States |
Other Details:
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Languages: eng Pagination: 373-9 Citation Subset: IM |
Affiliation:
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School of Pharmacy, University of Pittsburgh, Pennsylvania 15261, USA. KaneSL@msx.upmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Clinical Trials as Topic Electromyography Humans Intensive Care Units Length of Stay Male Multiple Organ Failure / complications Muscle Weakness / complications, therapy Phrenic Nerve / physiology Polyneuropathies / complications, physiopathology, therapy* Respiration, Artificial Retrospective Studies Sepsis / complications, physiopathology Systemic Inflammatory Response Syndrome / diagnosis, physiopathology Ventilator Weaning |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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