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Clinical outcomes of amniotıc membrane transplantatıon in patients with corneal and conjunctival disorders.
MedLine Citation:
PMID:  23305441     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Purpose: To evaluate the effectiveness of amniotic membrane transplantation (AMT) in management of corneal and conjunctival diseases in large clinical series. Methods: 130 patients who had undergone AMT between February 2004-March 2011 were evaluated. The cases were selected from two main groups: corneal (105) and conjunctival disorders (25). Results were analyzed by ANOVA test defining the outcomes as success, recurrence, and failure. P values less than 0.1 were defined as significant. The success criteria of the corneal group was complete re-epitelization of cornea in the first month and formation of a deep anterior chamber. The success criteria of conjunctival disorders was regarded as complete re-epitelization by the fifteenth day of follow-up. Results: The cornea healed satisfactorily 85.7% of the corneal group and the success rate of conjunctival group was 92% (p=0.524 for success and p=0.245 for recurrence). There was not a significant difference between subgroups (p=0.167 for cornea subgroups and p=1.00 for conjunctiva subgroups). Corneal epithelial defect rapidly healed and there was significant visual acuity improvement after AMT (p=0.001). Conclusion: AMT is effective to promote corneal healing in patients with persistent epithelial defect and appeared to be helpful after surgery to release pain. It can be successfully used as an alternative to conjunctival autograft for conjunctival surface reconstruction.
Authors:
Tuba Celik; Yasemin Arslan Katircioglu; Evin Singar; Mustafa Kosker; Koray Budak; Remzi Kasim; Sunay Duman
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Seminars in ophthalmology     Volume:  28     ISSN:  1744-5205     ISO Abbreviation:  Semin Ophthalmol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610759     Medline TA:  Semin Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  41-5     Citation Subset:  IM    
Affiliation:
Bolu Gerede State Hospital, Ophthalmology Department , Bolu , Turkey.
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