Document Detail

Clinical outcome of treatment cycles using preimplantation genetic diagnosis for structural chromosomal abnormalities.
MedLine Citation:
PMID:  11559915     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To explore oocyte recovery, embryo quality, the number of transferable embryos and pregnancy rate after preimplantation genetic diagnosis (PGD) in patients with structural chromosomal aberrations. METHODS: PGD was performed in seven couples with Robertsonian translocations (Rob), eight couples with reciprocal translocations (Rec), two couples with inversions and one couple with a deletion. A total of 43 treatment cycles were carried out. RESULTS: A total of 14.2 oocytes per cycle were retrieved. Fertilisation and cleavage rates were 63% and 58%, respectively. Of the biopsied embryos 20% were transferable. Comparison of the Rob and Rec group revealed no significant differences in number of oocytes, fertilisation or cleavage rates. The number of transferable embryos after biopsy was significantly higher in the Rob group than in the Rec group. When embryo transfer (ET) was performed the pregnancy rate did not differ between the Rob and the Rec groups. Twenty-eight embryo transfers (one or two embryos) were carried out leading to eight clinical pregnancies (29% per ET): two twins, four singletons, one miscarriage and one ectopic pregnancy. All the children are carriers of balanced chromosomal aberrations. CONCLUSION: An acceptable pregnancy rate can be achieved among couples with structural chromosomal abnormalities.
M Fridström; L Ahrlund-Richter; E Iwarsson; H Malmgren; J Inzunza; B Rosenlund; P Sjöblom; M Nordenskjöld; E Blennow; O Hovatta
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  21     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-17     Completed Date:  2001-11-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  781-7     Citation Subset:  IM    
Copyright Information:
Copyright 2001 John Wiley & Sons, Ltd.
Department of Clinical Sciences, Division of Obstetrics and Gynecology, Karolinska Institute, K 57 Huddinge University Hospital, S-141 86 Stockholm, Sweden.
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MeSH Terms
Chromosome Aberrations / diagnosis*
Chromosome Disorders
Embryo Transfer
Fertilization in Vitro
In Situ Hybridization, Fluorescence
Maternal Age
Oocytes / physiology
Pregnancy Outcome
Pregnancy Rate
Pregnancy, High-Risk
Preimplantation Diagnosis*

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