Document Detail

Clinical outcome of respiratory failure in patients requiring prolonged (greater than 24 hours) mechanical ventilation.
MedLine Citation:
PMID:  3743148     Owner:  NLM     Status:  MEDLINE    
Patients requiring prolonged (greater than 24 hours) mechanical ventilation have various conditions that result in respiratory failure. All patients requiring prolonged mechanical ventilation were subdivided into the following six groups: uncomplicated acute lung injury; respiratory failure complicated by multisystem failure; previous lung disease; trauma; other medical causes; and routine postoperative ventilation. During a one-year period, 327 patients required prolonged mechanical ventilation; acute lung injury and chronic obstructive pulmonary disease were the predominant conditions. Sepsis was both the major predisposing factor for and complication of acute lung injury. Mortality for patients with acute lung injury was 40 percent in the uncomplicated group and 81 percent in patients with acute lung injury complicated by multisystem failure. Acute respiratory failure in association with acute renal failure had a mortality of 89 percent. Number of organ systems involved also correlated with mortality. In patients with chronic obstructive pulmonary disease and pneumonitis or retained secretions, mortality was lower (30 percent), but a significant percentage of these patients (43 percent) became ventilator-dependent. Ventilator dependence did not significantly increase mortality during the course of respiratory failure.
D J Gillespie; H M Marsh; M B Divertie; J A Meadows
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Chest     Volume:  90     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1986 Sep 
Date Detail:
Created Date:  1986-10-03     Completed Date:  1986-10-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  364-9     Citation Subset:  AIM; IM    
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MeSH Terms
Lung Diseases, Obstructive / mortality
Middle Aged
Multiple Organ Failure
Pneumonia / mortality
Postoperative Complications / mortality
Respiration, Artificial*
Respiratory Distress Syndrome, Adult / mortality
Respiratory Insufficiency / mortality*,  therapy
Time Factors
Wounds and Injuries / mortality
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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