Document Detail

Clinical outcome of patients with diabetes mellitus and chronic total occlusion treated with drug-eluting stents.
MedLine Citation:
PMID:  19057029     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The prognosis of patients with chronic total occlusion (CTO) and diabetes mellitus treated with percutaneous coronary intervention (PCI) and drug-eluting stent (DES) implantation is unknown. METHODS: We compared the 12-month outcomes of 52 diabetic patients with CTO after successful PCI who underwent DES implantation with that of 47 patients with diabetes and CTO previously treated with bare-metal stents (BMS). Death, myocardial infarction and repeat PCI or coronary artery bypass surgery were considered as a combined primary endpoint. RESULTS: At 1-year follow up, the primary endpoint occurred in 6% (n = 3) of patients treated with DES and 23% (n = 11) of the patients treated with BMS (p = 0.01). One patient in the DES group and 3 patients in the BMS group died during follow up (p = 0.26). Stepwise logistic regression analysis identified DES (odds ratio [OR] = 12.9, 95% confidence interval [CI] 2.90-57.5; p = 0.0004) and final minimal lumen diameter (odds ratio [OR] = 10.1, 95% CI 1.81-56.4; p = 0.01) as independent correlates of major adverse cardiac events (MACE) at follow up. CONCLUSIONS: In patients with chronic total occlusion, DES were superior to bare-metal stents in reducing the MACE and should be considered a preferred treatment strategy for patients with diabetes and CTO undergoing PCI.
Francesco De Felice; Rosario Fiorilli; Antonio Parma; Marco Stefano Nazzaro; Alban Dibra; Carmine Musto; Antonella De Santis; Roberto Violini
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of invasive cardiology     Volume:  20     ISSN:  1557-2501     ISO Abbreviation:  J Invasive Cardiol     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-05     Completed Date:  2009-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8917477     Medline TA:  J Invasive Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  651-4     Citation Subset:  IM    
UO Cardiologia Interventistica Ospedale S Camillo, Rome, Italy.
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MeSH Terms
Aged, 80 and over
Angioplasty, Transluminal, Percutaneous Coronary*
Chronic Disease
Coronary Artery Disease / mortality,  therapy*
Diabetic Angiopathies / mortality,  therapy*
Drug-Eluting Stents*
Follow-Up Studies
Logistic Models
Middle Aged
Treatment Outcome
Reg. No./Substance:

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