Document Detail

Clinical outcome in patients with peripheral artery disease. Results from a prospective registry (FRENA).
MedLine Citation:
PMID:  18395163     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The risk of future cardiovascular events in patients with peripheral artery disease (PAD) is often underestimated. PATIENTS AND METHODS: FRENA is an ongoing, observational registry of consecutive outpatients with symptomatic PAD, coronary artery disease (CAD) or cerebrovascular disease (CVD). We compared the incidence of major cardiovascular events (i.e., myocardial infarction, ischemic stroke, critical limb ischemia, or cardiovascular death) during a 12-month follow-up period in a series of consecutive outpatients with PAD, CAD or CVD. RESULTS: As of December 2006, 1265 patients had been enrolled in FRENA who completed the 12-month follow-up. Of these, 417 patients (33%) had PAD, 474 (37%) had CAD, 374 (30%) had CVD. Patients with PAD had an increased incidence of major cardiovascular events per 100 patient-years: 17 (95% CI: 13-22) vs. 7.9 (5.5-11) in those with CAD, or 8.9 (6.1-13) in those with CVD. Compared to patients with CAD or CVD those with PAD had a similar incidence of myocardial infarction or stroke, but a higher incidence of critical limb ischemia, limb amputation and death. This incidence increased with the severity of the symptoms: 8.7 (95% CI: 5.3-13) in patients in Fontaine stage IIa; 25 (95% CI: 16-38) in stage IIb; 26 (95% CI: 13-47) in stage III; 42 (95% CI: 24-67) in stage IV. CONCLUSIONS: Our data confirm a higher incidence of major cardiovascular events for patients with PAD, as well as a correlation of these events with the severity of PAD.
Manuel Monreal; Lorenzo Alvarez; Blanca Vilaseca; Ramón Coll; Carmen Suárez; Jesús Toril; Carmen Sanclemente;
Related Documents :
1442773 - Comorbid conditions and correlations with mortality risk among 3,399 incident hemodialy...
19819453 - Plasma cystatin c for prediction of 1-year cardiac events in mediterranean patients wit...
7459313 - Driving performance of retinitis pigmentosa patients.
Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2007-10-31
Journal Detail:
Title:  European journal of internal medicine     Volume:  19     ISSN:  1879-0828     ISO Abbreviation:  Eur. J. Intern. Med.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-08     Completed Date:  2008-06-04     Revised Date:  2009-05-20    
Medline Journal Info:
Nlm Unique ID:  9003220     Medline TA:  Eur J Intern Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  192-7     Citation Subset:  IM    
Servicio de Medicina Interna, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Cerebrovascular Disorders / epidemiology*
Coronary Artery Disease / epidemiology*
Extremities / blood supply
Follow-Up Studies
Ischemia / epidemiology
Middle Aged
Myocardial Infarction / epidemiology
Peripheral Vascular Diseases / epidemiology*
Risk Factors
Severity of Illness Index
Spain / epidemiology
J N Alcalá / ; L López / ; J Bisbe / ; M Camafort / ; A Ceballos / ; R Coll / ; M Monreal / ; M T Pascual / ; J M Suriñach / ; J Toril / ; B Vilaseca / ; F Martínez / ; M Pérez / ; C Sanclemente / ; C Suárez / ; G Tiberio /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Electrocardiographic QT interval and cardiovascular reactivity in fibromyalgia differ from chronic f...
Next Document:  Admission characteristics predicting longer length of stay among elderly patients hospitalized for d...