Document Detail


Clinical outcome in patients with peripheral artery disease. Results from a prospective registry (FRENA).
MedLine Citation:
PMID:  18395163     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The risk of future cardiovascular events in patients with peripheral artery disease (PAD) is often underestimated. PATIENTS AND METHODS: FRENA is an ongoing, observational registry of consecutive outpatients with symptomatic PAD, coronary artery disease (CAD) or cerebrovascular disease (CVD). We compared the incidence of major cardiovascular events (i.e., myocardial infarction, ischemic stroke, critical limb ischemia, or cardiovascular death) during a 12-month follow-up period in a series of consecutive outpatients with PAD, CAD or CVD. RESULTS: As of December 2006, 1265 patients had been enrolled in FRENA who completed the 12-month follow-up. Of these, 417 patients (33%) had PAD, 474 (37%) had CAD, 374 (30%) had CVD. Patients with PAD had an increased incidence of major cardiovascular events per 100 patient-years: 17 (95% CI: 13-22) vs. 7.9 (5.5-11) in those with CAD, or 8.9 (6.1-13) in those with CVD. Compared to patients with CAD or CVD those with PAD had a similar incidence of myocardial infarction or stroke, but a higher incidence of critical limb ischemia, limb amputation and death. This incidence increased with the severity of the symptoms: 8.7 (95% CI: 5.3-13) in patients in Fontaine stage IIa; 25 (95% CI: 16-38) in stage IIb; 26 (95% CI: 13-47) in stage III; 42 (95% CI: 24-67) in stage IV. CONCLUSIONS: Our data confirm a higher incidence of major cardiovascular events for patients with PAD, as well as a correlation of these events with the severity of PAD.
Authors:
Manuel Monreal; Lorenzo Alvarez; Blanca Vilaseca; Ramón Coll; Carmen Suárez; Jesús Toril; Carmen Sanclemente;
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2007-10-31
Journal Detail:
Title:  European journal of internal medicine     Volume:  19     ISSN:  1879-0828     ISO Abbreviation:  Eur. J. Intern. Med.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-08     Completed Date:  2008-06-04     Revised Date:  2009-05-20    
Medline Journal Info:
Nlm Unique ID:  9003220     Medline TA:  Eur J Intern Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  192-7     Citation Subset:  IM    
Affiliation:
Servicio de Medicina Interna, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. mmonreal.germanstrias@gencat.net
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Cerebrovascular Disorders / epidemiology*
Comorbidity
Coronary Artery Disease / epidemiology*
Extremities / blood supply
Female
Follow-Up Studies
Humans
Incidence
Ischemia / epidemiology
Male
Middle Aged
Myocardial Infarction / epidemiology
Peripheral Vascular Diseases / epidemiology*
Registries
Risk Factors
Severity of Illness Index
Spain / epidemiology
Investigator
Investigator/Affiliation:
J N Alcalá / ; L López / ; J Bisbe / ; M Camafort / ; A Ceballos / ; R Coll / ; M Monreal / ; M T Pascual / ; J M Suriñach / ; J Toril / ; B Vilaseca / ; F Martínez / ; M Pérez / ; C Sanclemente / ; C Suárez / ; G Tiberio /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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