Document Detail

Clinical outcome in patients with complete pathologic response (pT0) to preoperative irradiation/chemo-irradiation operated for locally advanced or locally recurrent rectal cancer.
MedLine Citation:
PMID:  16180215     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The importance of pT0 stage after preoperative radiation/chemoradiation is unclear. METHODS: Four hundred and nineteen patients had preoperative irradiation (46-50 Gy/2 Gy fractions) for primary locally advanced (PLA) or locally recurrent (LR) rectal cancer. 141 PLA and 65 LR cases with R0 resections/M0 stage are studied. Two of the pT0 PLA patients had also been given sensitizing chemotherapy and two pT0 in the LR group had received pelvic hyperthermia as well. RESULTS: pT0 was achieved in 7% of 229 PLA and 8% of 190 LR patients. For the PLA group, actuarial 5-year survival of pT0 was 90% versus 53% for the pT > 0 group. The difference was statistically significant. At five years local recurrence was zero in pT0 patients versus 23% in pT > 0 (not significant). For the LR groups 5-year-survival was 62% for pT0 versus 45% for the other pT-stages, local recurrence was 17 and 35% respectively (not significant). The seemingly better results for pT0 cases of PLA cancers versus the LR ones did not reach statistical significance. CONCLUSION: pT0 after preoperative irradiation is associated with improved survival for pT0 cases of PLA. Our studies on pT0 LR was suggestive of an improvement in this group as well.
Johan N Wiig; Stein G Larsen; Svein Dueland; Karl-Erik Giercksky
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of surgical oncology     Volume:  92     ISSN:  0022-4790     ISO Abbreviation:  J Surg Oncol     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-28     Completed Date:  2005-10-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0222643     Medline TA:  J Surg Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  70-5     Citation Subset:  IM    
Department of Surgical Oncology, The Norwegian Radium Hospital, Oslo, Norway.
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MeSH Terms
Adenocarcinoma / drug therapy,  pathology,  radiotherapy*
Combined Modality Therapy
Middle Aged
Neoplasm Recurrence, Local
Preoperative Care
Rectal Neoplasms / drug therapy,  pathology,  radiotherapy*,  surgery
Survival Analysis

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