Document Detail


Clinical outcome following stimulation with highly purified hMG or recombinant FSH in patients undergoing their first treatment cycle of IVF or ICSI.
MedLine Citation:
PMID:  20602599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To test whether the clinical efficiency of recombinant FSH (rFSH) and highly purified human menotrophin (hMG) differs in terms of pregnancy and live birth rates during the first treatment cycle of IVF or ICSI. DESIGN: Prospective cohort study. SETTING: Department of Gynecology and Obstetrics, Rikshospitalet, Oslo University Hospital. STUDY POPULATION: Records of 1,136 infertile couples undergoing their first IVF (n = 682) or ICSI (n = 454) treatments were reviewed. The effect of hMG and rFSH was analyzed for the IVF and ICSI groups separately. METHODS: Patients received long term down-regulation with GnRH agonist and controlled ovarian hyperstimulation with hMG or rFSH. Oocytes were fertilized by IVF or ICSI. Embryos were transferred on Day 2. MAIN OUTCOME MEASURES: Primary outcome measures were pregnancy and live birth rates, secondary outcome measures were duration of treatment, doses of hMG or rFSH applied, number of oocytes retrieved and the number and quality of embryos obtained. RESULTS: Similar pregnancy and live birth rates were observed with hMG and rFSH. Compared to hMG, treatment cycles with rFSH were characterized by significantly shorter stimulation, lower gonadotrophin consumption, and increased number of oocytes and embryos. CONCLUSION: We conclude that rFSH and hMG are equivalent in terms of clinical efficacy.
Authors:
Sverre Bjercke; Tom Tanbo; Thomas Abyholm; Anne Omland; Hans Kristian Opøien; Peter Fedorcsak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  89     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  1053-60     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Oslo University Hospital, Rikshospitalet, Oslo, Norway. sverre.bjercke@rikshospitalet.no
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MeSH Terms
Descriptor/Qualifier:
Adult
Buserelin / therapeutic use
Embryo, Mammalian
Female
Fertility Agents, Female / therapeutic use*
Fertilization in Vitro
Follicle Stimulating Hormone / therapeutic use*
Hormones / therapeutic use*
Humans
Live Birth*
Menotropins / therapeutic use*
Oocytes
Ovulation Induction / methods*
Pregnancy
Pregnancy Rate*
Prospective Studies
Sperm Injections, Intracytoplasmic
Time Factors
Chemical
Reg. No./Substance:
0/Fertility Agents, Female; 0/Hormones; 57982-77-1/Buserelin; 61489-71-2/Menotropins; 9002-68-0/Follicle Stimulating Hormone

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