| Clinical outcome and angiographic results with novel polysulfone polymer coating paclitaxel eluting stent in real-world clinical practice: a clinical centre registry. | |
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MedLine Citation:
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PMID: 20885360 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The Intek-Apollo stent (Switzerland) employs a polysulfone polymer coating which has demonstrated low interaction with blood and high thrombo-resistance. The aim of this study was to assess the clinical and angiographic outcomes after Intek-Apollo stent utilisation in a real-world setting. MATERIAL/METHODS: A total of 130 patients (77.7% males) were enrolled with 174 lesions in native coronary arteries (92.4%), saphenous vein grafts (7.5%) and in-stent restenosis (6.3%). Indications for stenting were stable coronary artery disease (CAD) 52.3%, acute coronary syndrome (ACS) 37.7% and STEMI 10%. Clinical follow-up and coronary angiography (after symptoms occurrence or positive stress test) was performed at 6 and 12 months.The primary end points were target lesion revascularization (TLR) and target vessel revascularization (TVR), while secondary end points were major adverse cardiac events (MACE) during the follow-up period. RESULTS: The mean age of patients included was 61.62±11.13 years. Complex lesions treatment (ostial, bifurcation) reached 13.7%. Mean stenosis diameter was 83.52±10.5%. Reference vessel diameter was 2.85±0.39 mm with a mean lesion length of 14.66±4.5mm. Average stent size was 2.93±0.39mm × 16.6±4.73 mm. At 15±3 months, primary events included TLR (4.6%), TVR (4.6%) and MACE (2.3%). There was 1one myocardial infarction and no cardiac death). No incidence of early or late stent thrombosis was demonstrated. CONCLUSIONS: Intek-Apollo stent implantation is safe and efficient in a real world population. The unique properties of polysulfone polymer coating can effectively protect from late stent thrombosis and lead to reduced rates of TLR, TVR and MACE. |
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Authors:
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Gerasimos Gavrielatos; Prodromos L Anthopoulos; Loukas K Pappas; Isidoros Gavaliatsis; Anastasios Salachas; Georgios Ifantis; Ioannis Antonelis |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Medical science monitor : international medical journal of experimental and clinical research Volume: 16 ISSN: 1643-3750 ISO Abbreviation: Med. Sci. Monit. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2011-04-18 Revised Date: 2011-06-14 |
Medline Journal Info:
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Nlm Unique ID: 9609063 Medline TA: Med Sci Monit Country: Poland |
Other Details:
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Languages: eng Pagination: MT77-82 Citation Subset: IM |
Affiliation:
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2nd Department of Cardiology, Evaggelismos General Hospital, Athens, Greece. makisgab@yahoo.gr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Coated Materials, Biocompatible / therapeutic use Coronary Angiography / adverse effects Coronary Artery Disease / complications, radiography, therapy Coronary Disease / complications, drug therapy, radiography Coronary Vessels / pathology Drug-Eluting Stents* Follow-Up Studies Humans Male Middle Aged Myocardial Infarction / complications, epidemiology, radiography Paclitaxel / administration & dosage*, therapeutic use Polymers / therapeutic use Registries Sulfones / therapeutic use Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Coated Materials, Biocompatible; 0/Polymers; 0/Sulfones; 25135-51-7/polysulfone P 1700; 33069-62-4/Paclitaxel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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