Document Detail

Clinical outcome of 193 extracardiac Fontan patients: the first 15 years.
MedLine Citation:
PMID:  16697327     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We sought to evaluate the mid-term outcome of hospital survivors with extracardiac Fontan circulation. BACKGROUND: Few data exist about the mid-term and long-term results of the extracardiac Fontan operation. METHODS: From November 1988 to November 2003, 221 patients underwent an extracardiac Fontan procedure as primary (9 patients) or secondary (212 patients) palliation, at a mean age of 72.2 months (range 13.1 to 131.3 months). A total of 165 of 193 early survivors underwent programmed noninvasive follow-up evaluations and at least one cardiac catheterization. RESULTS: The overall survival, including operative deaths, was 85% at 15 years. Freedom from late failure among hospital survivors is 92% at 15 years. A total of 127 of 165 survivors (77%) were in New York Heart Association functional class I. The incidence of late major problems was 24% (42 major problems in 36 of 165 patients): 19 patients had arrhythmias (11%), 5 patients had obstruction of the extracardiac conduit (3%) and 6 of the left pulmonary artery (3.5%), and 5 patients experienced ventricular failure (3%), leading to heart transplantation in 3 patients. Protein-losing enteropathy was found in two patients (1%). The incidence of late re-interventions was 12.7% (21 of 165 patients, including 15 epicardial pacemaker implantations). Four patients died (2.3%), two after heart transplantation. CONCLUSIONS: After 15 years of follow-up, the overall survival, the functional status, and the cardiopulmonary performance of survivors of the extracardiac Fontan procedure compare favorably with other series of patients who underwent the lateral tunnel approach. The incidence of late deaths, obstructions of the cavopulmonary pathway, re-interventions, and arrhythmias is lower than that reported late after other Fontan-type operations.
Salvatore Giannico; Fatma Hammad; Antonio Amodeo; Guido Michielon; Fabrizio Drago; Attilio Turchetta; Roberto Di Donato; Stephen P Sanders
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Publication Detail:
Type:  Journal Article     Date:  2006-04-27
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  47     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-15     Completed Date:  2006-05-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2065-73     Citation Subset:  AIM; IM    
Department of Pediatric Cardiology and Cardiac Surgery, Rome, Italy.
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MeSH Terms
Cardiovascular Diseases / etiology,  surgery
Cardiovascular Surgical Procedures
Child, Preschool
Exercise Test
Exercise Tolerance
Follow-Up Studies
Fontan Procedure* / adverse effects
Heart Defects, Congenital / surgery*
Pulmonary Artery / surgery
Recovery of Function
Respiratory Function Tests
Survival Analysis
Treatment Outcome
Vascular Patency
Vena Cava, Inferior / surgery

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