| Clinical observations in children after prenatal benzodiazepine exposure. | |
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MedLine Citation:
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PMID: 1983095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eight children excessively exposed to benzodiazepines (BZD) in utero are described. Five of the 8 mothers admitted regular use of BZD and in 3 mothers, stored serum from early pregnancy could be analysed and found positive for BZD and its metabolite. All the children had similar dysmorphic features, in addition, 1 child had aplasia of one kidney and 2 had cleft palate. At follow-up 2 children had become microcephalic. 2 were severely mentally retarded, 5 had a mild mental retardation and only 1 was of normal intelligence. In a case-control study, 4 neonatal diagnoses of congenital malformations, in our experience characteristic of fetal BZD exposure, were chosen as inclusion criteria. In 8 of 18 cases, blood samples from early pregnancy were positive for BZD as compared to 2 of 60 control samples. An association between BZD-positive serum tests and the particular diagnoses could be demonstrated (p = 0.00006). |
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Authors:
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L Laegreid |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Developmental pharmacology and therapeutics Volume: 15 ISSN: 0379-8305 ISO Abbreviation: Dev Pharmacol Ther Publication Date: 1990 |
Date Detail:
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Created Date: 1991-08-09 Completed Date: 1991-08-09 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8003947 Medline TA: Dev Pharmacol Ther Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 186-8 Citation Subset: IM |
Affiliation:
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Department of Pediatrics II, East Hospital, Gothenburg University, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced* Adult Anti-Anxiety Agents / adverse effects* Benzodiazepines Cleft Palate / chemically induced* Female Humans Infant, Newborn Male Maternal-Fetal Exchange Mental Retardation / chemically induced* Microcephaly / chemically induced* Pregnancy Prenatal Exposure Delayed Effects* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Anxiety Agents; 12794-10-4/Benzodiazepines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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