Document Detail

Clinical observation of treatment of hypertension with calcium.
MedLine Citation:
PMID:  8031553     Owner:  NLM     Status:  MEDLINE    
The effect of oral calcium supplementation (1000 mg/day) on hypertension was studied in 57 borderline and mild-to-moderate hypertensive patients in a randomized, double-blind, placebo-controlled study for 14 weeks. Twenty-five patients from the above groups (11 from the calcium-treated group and 14 from the placebo group) were studied in a crossover fashion for 14 more weeks. The high calcium intake lowered systolic blood pressure by 17 mm Hg (P < .01), and diastolic blood pressure by 11 mm Hg (P < .01). Fifty percent of the calcium-treated patients showed a significant antihypertensive effect and were termed calcium responders. In the crossover study, serum sodium was lower after taking calcium than after placebo intake (P < .05). Pretreatment plasma free calcium content of the calcium-responsive patients was significantly lower (P < .05) than in the calcium nonresponsive patients, and was highly significantly increased (P < .01) after administering calcium. The result showed that oral calcium supplementation can lower blood pressure in a significant fraction of essential hypertensive subjects, and that the free calcium level in plasma may help identify calcium-responsive individuals. While the mechanism by which increased calcium intake lowers blood pressure in hypertension is still undetermined, these data support an underlying relationship between hypertension and calcium and possibly sodium metabolism.
C Zhou; S Fan; L Zhou; Y Ni; T Huang; Y Shi
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of hypertension     Volume:  7     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-08-12     Completed Date:  1994-08-12     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  363-7     Citation Subset:  IM    
Research Institute of Cardiovascular Diseases, Second Affiliated Hospital of Tianjin Medical College, Peoples' Republic of China.
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MeSH Terms
Administration, Oral
Blood Pressure / drug effects
Calcium / blood
Calcium Carbonate / therapeutic use*
Double-Blind Method
Hypertension / blood,  drug therapy*,  physiopathology
Middle Aged
Sodium / blood
Reg. No./Substance:
471-34-1/Calcium Carbonate; 7440-23-5/Sodium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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