Document Detail


Clinical and neuropathological characteristics of hippocampal sclerosis: a community-based study.
MedLine Citation:
PMID:  12117357     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Hippocampal sclerosis (HS) is a neuropathologic finding characterized by neuronal loss and gliosis in the CA-1 and subiculum of the hippocampus. Previous studies of HS have shown that this is a common postmortem finding in elderly subjects with dementia. However, these studies were from selected samples and therefore are not necessarily representative of patients seen in the general medical community. OBJECTIVES: To examine the clinical and pathologic characteristics of HS in a community-based case series of dementia and to compare these characteristics with those observed in subjects with Alzheimer disease (AD) from the same study sample. METHODS: One hundred thirty-four autopsy cases were available from a community-based registry of dementia. Sixteen cases (12%) had a postmortem diagnosis of HS. Thirty-two comparison control cases with a neuropathologic diagnosis of AD were selected from the same files. Each case of HS was reviewed for HS neuropathologic features, including severity, distribution, and additional pathologic processes. Blinded review of clinical characteristics for the HS and control groups was performed to assess risk factors. RESULTS: There was a wide range of severity and distribution of HS lesions between cases and substantial variability in lesion severity and age within individual cases. Serial neuropsychologic and behavioral assessments revealed similar clinical features and rates of dementia progression between HS and AD groups. Of all neuropsychologic tests performed at enrollment, only enhanced performance on Trails A differentiated the HS from the AD group (64 seconds, 0 errors vs 114 seconds, 0.6 errors; P< or = .05). The number of AD cases with at least 1 apolipoprotein epsilon 4 allele was significantly greater than the HS cases (61% vs 31%; chi(2) = 3.81, P< or = .05). Although medical record review indicated higher frequencies of clinical stroke and neuroradiologic white matter abnormalities in the HS group, risk factors for vascular disease and neuropathologic evidence of cerebrovascular disease did not differ between the groups. CONCLUSIONS: Our results suggest that HS is a frequent pathologic finding in community-based dementia. Individuals with HS have similar initial symptoms and rates of dementia progression to those with AD and therefore are frequently misclassified as having AD. Our clinical and pathologic findings suggest that HS has characteristics of a progressive disorder although the underlying cause remains elusive.
Authors:
James B Leverenz; Christina M Agustin; Debby Tsuang; Elaine R Peskind; Steven D Edland; David Nochlin; Lillian DiGiacomo; James D Bowen; Wayne C McCormick; Linda Teri; Murray A Raskind; Walter A Kukull; Eric B Larson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of neurology     Volume:  59     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-15     Completed Date:  2002-07-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1099-106     Citation Subset:  AIM; IM    
Affiliation:
Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, 116 MIRECC, Seattle, WA 98108, USA. leverenz@u.washington.edu
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MeSH Terms
Descriptor/Qualifier:
Age of Onset
Aged
Aged, 80 and over
Alzheimer Disease / genetics,  pathology*,  psychology
Apolipoproteins E / genetics
Dementia / genetics,  pathology*,  psychology
Female
Genotype
Hippocampus / pathology*
Humans
Male
Medical Records
Neuropsychological Tests
Registries
Retrospective Studies
Sclerosis
Severity of Illness Index
Grant Support
ID/Acronym/Agency:
AG05136/AG/NIA NIH HHS; AG06781/AG/NIA NIH HHS; R01AG10845/AG/NIA NIH HHS; U01AG06781/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoproteins E

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