| Clinical and neuroimaging evidence of interictal cerebellar dysfunction in FHM2. | |
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MedLine Citation:
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PMID: 19673908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We used multimodal magnetic resonance (MR) techniques [brain diffusion-weighted magnetic resonance imaging, diffusion-weighted imaging (DWI), proton MR spectroscopy (MRS), (1)H-MRS; and skeletal muscle phosphorous MRS, (31)P-MRS] to investigate interictal brain microstructural changes and tissue energy metabolism in four women with genetically determined familial hemiplegic migraine type 2 (FHM2), belonging to two unrelated families, compared with 10 healthy women. Brain DWI revealed a significant increase of the apparent diffusion coefficient median values in the vermis and cerebellar hemispheres of FHM2 patients, preceding in two subjects the onset of interictal cerebellar deficits. (31)P-MRS revealed defective energy metabolism in skeletal muscle of FHM2 patients, while brain (1)H-MRS showed a mild pathological increase in lactate in the lateral ventricles of one patient and a mild reduction of cortical N-acetyl-aspartate to creatine ratio in another one. Our MRS results showed that a multisystem energy metabolism defect in FHM2 is associated with microstructural cerebellar changes detected by DWI, even before the onset of cerebellar symptoms. |
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Authors:
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D Grimaldi; C Tonon; S Cevoli; G Pierangeli; E Malucelli; G Rizzo; S Soriani; P Montagna; B Barbiroli; R Lodi; P Cortelli |
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Publication Detail:
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Type: Journal Article Date: 2010-02-01 |
Journal Detail:
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Title: Cephalalgia : an international journal of headache Volume: 30 ISSN: 1468-2982 ISO Abbreviation: Cephalalgia Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-10-01 Completed Date: 2011-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200710 Medline TA: Cephalalgia Country: England |
Other Details:
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Languages: eng Pagination: 552-9 Citation Subset: IM |
Affiliation:
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Department of Neurological Sciences, University of Bologna, Bologna, Italy. daniela.grimaldi@unibo.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cerebellar Diseases / metabolism, pathology, physiopathology* Cerebellum / metabolism, pathology, physiopathology Diffusion Magnetic Resonance Imaging Female Humans Migraine with Aura / metabolism, pathology, physiopathology Muscle, Skeletal / metabolism, pathology, physiopathology* |
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