Document Detail

Clinical and neurobiological aspects of long-term administration of psychotropic drugs
MedLine Citation:
PMID:  1678309     Owner:  NLM     Status:  MEDLINE    
In neuroleptic therapy for psychotic illnesses, clinical improvement occurs much later than central dopamine blockade, and its time course varies widely among patients. A hypothesis explaining neuroleptic-responsive illness cannot be explained by dopamine blockade alone. Nevertheless, experimental data suggest that this mechanism may be a step in the therapeutic process for schizophrenia. Explanations are suggested for the time lag in therapeutic response for neuroleptics, including the hypothesis of delayed inactivation of mid-brain dopamine neurones. Chronic benzodiazepine treatment elicits adaptive responses in the CNS that are manifested as functional tolerance and physical dependence. Possible mechanisms involved in such a profound alteration of neuronal functioning are suggested. Down regulation of benzodiazepine receptors has been shown to be related to functional tolerance under certain conditions. The effect of repeated treatment with antidepressants is compatible with the hypothesis that changes in central monoamine transmission are involved in the activity of these drugs. Beta-adrenergic receptors are desensitized and their density is decreased; alpha-2 adrenoreceptors sensitivity is reduced, and post-synaptic serotoninergic receptors sensitivity is increased. It remains to be clarified whether some of the changes have larger role than others or whether they all contribute to the psychotropic drug activity in the therapeutic process.
M Bourin; J Bradwejn
Publication Detail:
Type:  English Abstract; Journal Article; Review    
Journal Detail:
Title:  Canadian journal of psychiatry. Revue canadienne de psychiatrie     Volume:  36     ISSN:  0706-7437     ISO Abbreviation:  Can J Psychiatry     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-09-13     Completed Date:  1991-09-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7904187     Medline TA:  Can J Psychiatry     Country:  CANADA    
Other Details:
Languages:  fre     Pagination:  260-4     Citation Subset:  IM    
Département de pharmacologie, Faculté de médecine, Université de Nantes, France.
Vernacular Title:
Aspects cliniques et neurobiologiques de l'administration à long terme des psychotropes.
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MeSH Terms
Anti-Anxiety Agents / adverse effects,  therapeutic use
Antidepressive Agents / adverse effects,  therapeutic use
Antipsychotic Agents / adverse effects,  therapeutic use
Brain / drug effects*,  physiopathology
Mental Disorders / drug therapy*,  physiopathology,  psychology
Psychotropic Drugs / administration & dosage*,  adverse effects
Receptors, Neurotransmitter / drug effects*,  physiology
Reg. No./Substance:
0/Anti-Anxiety Agents; 0/Antidepressive Agents; 0/Antipsychotic Agents; 0/Psychotropic Drugs; 0/Receptors, Neurotransmitter; 12794-10-4/Benzodiazepines

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