Document Detail

Clinical and morphologic spectrum of renal involvement in patients with mixed cryoglobulinemia without evidence of hepatitis C virus infection.
MedLine Citation:
PMID:  19910748     Owner:  NLM     Status:  MEDLINE    
Hepatitis C virus (HCV) infection represents, by far, the major cause of mixed cryoglobulinemia (MC). The renal disease associated with this pathological condition is now well described. By contrast, renal involvement in patients with MC not associated with HCV has been only poorly described, and few cases have been reported. We analyzed the demographic, clinical, and laboratory features and outcome in patients presenting with renal disease associated with MC not related to HCV infection. Records of 20 patients with MC and renal disease, with no evidence of HCV by serology and polymerase chain reaction analysis, were retrospectively analyzed. Renal biopsies and extensive searches for lymphoproliferative disorder were performed in all patients at presentation. MC was related to primary Sjögren Syndrome (pSS) in 9 patients, and to non-Hodgkin lymphoma in 1 patient, while MC was classified as essential in the remaining 10 cases. Renal involvement was characterized by microscopic hematuria in all patients, nephrotic range proteinuria in 75% of patients, hypertension in 80% of patients, and renal failure in 85% of patients (mean glomerular filtration rate, 46 mL/min per 1.73 m). Membranoproliferative glomerulonephritis with subendothelial deposits was observed in all kidney specimens. Skin vasculitis was the main extrarenal manifestation. In all patients, cryoglobulinemia was classified as type II MC, characterized by monoclonal IgMkappa and polyclonal IgG. Most patients (17/20) were treated with steroids or immunosuppressive agents, or both. Initial renal remission was observed in 94% of patients. However, renal relapse occurred in most patients, with 10% reaching end-stage renal disease. Three patients with essential MC developed B-cell lymphoma 36-48 months after the diagnosis of MC. Unexpectedly, B-cell lymphoma induced by Epstein-Barr virus infection occurred in only 1 of the 9 pSS patients. Forty percent of patients died as a result of extrarenal causes.Renal disease associated with MC unrelated to HCV is characterized by the high prevalence of pSS (45%), the finding of CD20+ B-lymphocyte nodular infiltrates in the kidney interstitium, and a high incidence of overt B-cell lymphoma during follow-up. These findings emphasize the need for repetitive clinical evaluation in those patients.
Marie Matignon; Patrice Cacoub; Magali Colombat; David Saadoun; Isabelle Brocheriou; Béatrice Mougenot; Françoise Roudot-Thoraval; Philippe Vanhille; Olivier Moranne; Eric Hachulla; Pierre-Yves Hatron; Jean-Paul Fermand; Fadi Fakhouri; Pierre Ronco; Emmanuelle Plaisier; Philippe Grimbert
Related Documents :
19910748 - Clinical and morphologic spectrum of renal involvement in patients with mixed cryoglobu...
12042898 - Long-term follow-up of type iii membranoproliferative glomerulonephritis in children.
12883968 - Focal segmental membranoproliferative glomerulonephritis in children.
6864688 - Penicillamine compared to previous chrysotherapy in rheumatoid arthritis.
17540408 - Brain perfusion and vep reactivity in occipital and parietal areas are associated to re...
8011198 - Patients with ruptured intracranial saccular aneurysms: clinical features and outcome a...
Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Medicine     Volume:  88     ISSN:  1536-5964     ISO Abbreviation:  Medicine (Baltimore)     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-13     Completed Date:  2009-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985248R     Medline TA:  Medicine (Baltimore)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  341-8     Citation Subset:  AIM; IM    
Nephrology and Transplantation Department, Henri Mondor Hospital, AP-HP, Institut Francilien de Recherche en Néphrologie et Transplantation and Paris XII University, Créteil, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cryoglobulinemia / drug therapy,  etiology,  pathology*
Hepatitis C / pathology
Kidney / pathology*
Kidney Diseases / complications,  pathology
Middle Aged
Proteinuria / pathology
Retrospective Studies
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clinical and Serologic Baseline and Follow-Up Features of Syphilis According to HIV Status in the Po...
Next Document:  Independent and Additive Interactive Effects Among Tumor Necrosis Factor-alpha Polymorphisms, Substa...