Document Detail


Clinical, morphologic, and cytogenetic characteristics of patients with lymphoid malignancies characterized by both t(14;18)(q32;q21) and t(8;14)(q24;q32) or t(8;22)(q24;q11).
MedLine Citation:
PMID:  2278969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Six patients with an aggressive leukemia/lymphoma disorder had a t(14;18) as well as either a t(8;14) (three patients) or a t(8;22) (three patients). Leukemia cells from all three patients with the t(8;22) had a mature B cell phenotype (Smlg + and TdT-), whereas two of three patients with the t(8;14) had a pre-B phenotype and were Smlg-. None of the patients with the t(8;22) had a prior history of follicular lymphoma, whereas two of the three patients with the t(8;14) had had a follicular lymphoma. The clinical, cytogenetic, and morphologic characteristics of these six patients along with eight previously reported cases with both the t(14;18) and the t(8;14), the t(8;22) or the t(2;8) are discussed.
Authors:
M Thangavelu; O Olopade; E Beckman; J W Vardiman; R A Larson; T W McKeithan; M M Le Beau; J D Rowley
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genes, chromosomes & cancer     Volume:  2     ISSN:  1045-2257     ISO Abbreviation:  Genes Chromosomes Cancer     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1991-03-08     Completed Date:  1991-03-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9007329     Medline TA:  Genes Chromosomes Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  147-58     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Chicago, IL 60637.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blast Crisis / genetics
Burkitt Lymphoma / genetics,  pathology
Chromosome Deletion
Chromosomes, Human, Pair 14 / ultrastructure*
Chromosomes, Human, Pair 22 / ultrastructure*
Chromosomes, Human, Pair 8 / ultrastructure*
Female
Gene Rearrangement
Genes, Immunoglobulin
Humans
Immunophenotyping
Lymphoma, Follicular / genetics,  pathology
Lymphoma, Non-Hodgkin / genetics*,  pathology
Male
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*,  pathology
Translocation, Genetic*
Grant Support
ID/Acronym/Agency:
CA 42557/CA/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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