|Clinical and molecular genetic features of congenital spinal muscular atrophy.|
|PMID: 8957014 Owner: NLM Status: MEDLINE|
|A neonate presented with the fetal hypokinesia sequence and signs of spinal muscular atrophy (SMA). Severe pathological changes including ballooned neurons and neuronophagia were found not only in the motor nerve nuclei but also in the thalamic, cerebellar, and brainstem nuclei as well as in the dorsal root ganglia. Direct DNA analysis showed the presence of a chimeric SMN gene, with a rearrangement occurring between exon 7 of the centromeric SMN gene and exon 8 of the telomeric SMN gene. Circumstantial evidence suggests that only a single copy of this gene is present, with transcriptional characteristics of a centromeric SMN gene. In addition, a homozygous deletion in the NAIP genes was demonstrated. This observation demonstrates that at least some cases with fetal hypokinesia and SMA may represent the severe end of a spectrum of disorders caused by deletions in the SMA locus on chromosome 5q13. In addition, these findings are compatible with a modifying role for the centromeric SMN genes and the NAIP genes in the severity of the SMA phenotype.|
|K Devriendt; M Lammens; E Schollen; C Van Hole; R Dom; H Devlieger; J J Cassiman; J P Fryns; G Matthijs|
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|Type: Case Reports; Journal Article|
|Title: Annals of neurology Volume: 40 ISSN: 0364-5134 ISO Abbreviation: Ann. Neurol. Publication Date: 1996 Nov|
|Created Date: 1997-01-23 Completed Date: 1997-01-23 Revised Date: 2008-11-21|
Medline Journal Info:
|Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: UNITED STATES|
|Languages: eng Pagination: 731-8 Citation Subset: IM|
|Center for Human Genetics, University Hospital Leuven, Belgium.|
|APA/MLA Format Download EndNote Download BibTex|
Brain / pathology*
Brain Stem / pathology
Cerebellum / pathology
Chromosomes, Human, Pair 5*
Ganglia, Spinal / pathology
Motor Neurons / pathology
Nerve Tissue Proteins / genetics*
Neuronal Apoptosis-Inhibitory Protein
Neurons / pathology
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational*
Ribonucleoproteins, Small Nuclear*
Spinal Muscular Atrophies of Childhood / genetics*, pathology*
Thalamic Nuclei / pathology
Thalamus / pathology
snRNP Core Proteins
|0/Autoantigens; 0/DNA Primers; 0/NAIP protein, human; 0/Nerve Tissue Proteins; 0/Neuronal Apoptosis-Inhibitory Protein; 0/Ribonucleoproteins, Small Nuclear; 0/SNRPN protein, human; 0/snRNP Core Proteins|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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