| Clinical and molecular genetic factors affecting postoperative seizure control of 183 Chinese adult patients with low-grade gliomas. | |
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MedLine Citation:
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PMID: 21895881 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background and purpose: Seizures are a common symptom of patients with primary brain tumors, particularly low-grade gliomas (LGGs). Poor seizure control after surgery has a great adverse impact on quality of life in these patients. The present study aimed to identify clinical and molecular genetic factors that influence postoperative seizure control. Methods: A series of 183 LGGs were analyzed by denaturing high-performance liquid chromatography (DHPLC) for 1p and 19q status and by immunohistochemical staining for expression of several molecular markers (P53, Ki-67, MMP-9 and MGMT), with particular emphasis on correlations with postoperative seizure control. Univariate and multivariate logistic regression analyses were used for statistic analysis. Results: Of the 183 patients, 134 (73.2%) patients presented with seizures. Most of oligodendrogliomas and oligoastrocytomas had LOH 1p and LOH 19q, which were rarely seen in combination in astrocytomas (P < 0.001). Oligodendroglial tumors were more likely to locate in frontal lobe (P = 0.011) and present calcification on MRI (P = 0.024). Temporal location (P = 0.014), and high expression of mutated P53 (P = 0.011) were associated with astrocytomas. Patients achieved much better seizure control after gross-total resection (P < 0.001) than after subtotal resection. Patients without LOH 19q were more likely to have poor seizure control (P = 0.004) than those with this alteration. Ki-67 was an independent molecular marker predicting poor seizure control (P = 0.016) if over expressed. Conclusions: Gross total resection of the tumor, LOH 19q and low Ki-67 expression were associated with favorable seizure control after surgery for the patients with LGGs. The possible involvement of other factors should be investigated further. |
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Authors:
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G You; L Huang; P Yang; W Zhang; W Yan; Y Wang; Z Bao; S Li; S Li; G Li; T Jiang |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-6 |
Journal Detail:
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Title: European journal of neurology : the official journal of the European Federation of Neurological Societies Volume: - ISSN: 1468-1331 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506311 Medline TA: Eur J Neurol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Author(s). European Journal of Neurology © 2011 EFNS. |
Affiliation:
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Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China Department of Neuropathology, Beijing Neurosurgical Institute, Beijing, China. |
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