Document Detail

Clinical, microbiological, and immunological studies in patients with immunoglobulin deficiencies and gastrointestinal disorders.
MedLine Citation:
PMID:  4557306     Owner:  NLM     Status:  MEDLINE    
Seven patients with gastrointestinal disorders and deficiencies of serum and secretory immunoglobulins were evaluated clinically, microbiologically, and immunologically. Five patients had generalized deficiencies of immunoglobulins; two were selectively deficient. Diarrhoea and malabsorption in six of the seven patients were at least partially explained. Four of the five patients with generalized hypogammaglobulinaemia had intestinal infestation with Giardia lamblia; in three of the five, excessive numbers of anaerobic bacteria were cultured from small bowel fluids. Despite much variability in relative severity of patients' respiratory and gastrointestinal tract symptoms, deficiencies of mucosal immunocytes and immunoglobulins in nasopharyngeal and gastrointestinal tract tissues and secretions were similar. Except for one selectively IgA-deficient patient, all patients were deficient in IgE. The study characterizes in greater detail than heretofore the gastrointestinal disorders associated with immunoglobulin deficiency states.
W R Brown; D Butterfield; D Savage; T Tada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  13     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1972 Jun 
Date Detail:
Created Date:  1972-09-06     Completed Date:  1972-09-06     Revised Date:  2010-09-13    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  441-9     Citation Subset:  AIM; IM    
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MeSH Terms
Agammaglobulinemia / complications*,  microbiology
Diarrhea / etiology
Fluorescent Antibody Technique
Gastrointestinal Diseases / complications*,  immunology
Giardia / isolation & purification
Hemagglutination Inhibition Tests
Immunoglobulin A
Immunoglobulin E
Immunologic Deficiency Syndromes / complications*
Intestines / microbiology
Jejunum / pathology
Lectins / pharmacology
Lymphocytes / metabolism
Middle Aged
Nasopharynx / pathology
Stomach / pathology
Thymidine / metabolism
Reg. No./Substance:
0/Immunoglobulin A; 0/Lectins; 10028-17-8/Tritium; 37341-29-0/Immunoglobulin E; 50-89-5/Thymidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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