Document Detail

Clinical and microbiological effects of adjunctive, locally delivered chlorhexidine on patients with chronic periodontitis.
MedLine Citation:
PMID:  20593635     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The impact of a locally delivered chlorhexidine chip (Periochip) on clinical and microbiological parameters of chronic periodontitis requires further documentation. The aim of the present study was to investigate the effects of the chip as an adjunct to mechanical treatment of chronic periodontitis. METHODS: Fifty patients with chronic periodontitis were randomized into two groups. The test group (n = 25) received scaling and root planing and adjunctive Periochip in four pockets. The control group (n = 25) received scaling and root planing only. Clinical indices (probing depth, probing attachment level, bleeding on probing) were assessed at baseline, three and six months. Subgingival samples were analyzed at baseline, three weeks, three and six months after treatment for levels of eight bacterial species using "checkerboard" DNA-DNA hybridization. RESULTS: The targeted difference of probing depth of 2 mm between groups was not observed. Both treatments resulted in improvement of clinical indices and non-statistically significant differences were observed between the two groups at any time point, with the exception of bleeding on probing at three months (ANOVA, p < 0.05). No major differences were observed concerning levels of important periodontal pathogens (Mann-Whitney test, p < or = 0.05). CONCLUSIONS: In this small, six-month, phase 4 trial, no differences in mean probing depth reduction or "red-complex" periodontal pathogens were detected for patients with chronic periodontitis treated with adjunctive chlorhexidine chip (single administration) as compared to patients treated with scaling and root planing alone.
Dimitra Sakellari; Sakellari Dimitra; Ioannis Ioannidis; Ioannidis Ioannis; Malama Antoniadou; Antoniadou Malama; Theodora Slini; Slini Theodora; Antonis Konstantinidis; Konstantinidis Antonis
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Publication Detail:
Type:  Clinical Trial, Phase IV; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the International Academy of Periodontology     Volume:  12     ISSN:  1466-2094     ISO Abbreviation:  J Int Acad Periodontol     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-07-02     Completed Date:  2010-07-29     Revised Date:  2010-07-30    
Medline Journal Info:
Nlm Unique ID:  100888553     Medline TA:  J Int Acad Periodontol     Country:  England    
Other Details:
Languages:  eng     Pagination:  20-6     Citation Subset:  D    
Department of Preventive Dentistry, Periodontology and Implant Biology, Aristotle University of Thessaloniki, Greece.
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MeSH Terms
Analysis of Variance
Anti-Infective Agents, Local / administration & dosage*
Chlorhexidine / administration & dosage*
Chronic Periodontitis / drug therapy*,  microbiology
Combined Modality Therapy
DNA, Bacterial / analysis
Dental Plaque / drug therapy,  microbiology
Dental Scaling
Drug Delivery Systems
Gram-Negative Anaerobic Bacteria / drug effects*,  genetics
Longitudinal Studies
Middle Aged
Periodontal Index
Periodontal Pocket / drug therapy*,  microbiology
Severity of Illness Index
Treatment Outcome
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/DNA, Bacterial; 55-56-1/Chlorhexidine
Erratum In:
J Int Acad Periodontol. 2010 Apr;12(2):62
Note: Dimitra, Sakellari [corrected to Sakellari, Dimitra]; Ioannis, Ioannidis [corrected to Ioannidis, Ioannis]; Malama, Antoniadou [corrected to Antoniadou, Malama]; Theodora, Slini [corrected to Slini, Theodora]; Antonis, Konstantinidis [corrected to Konstantinidis, Antonis]

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