| Clinical and microbiological effects of adjunctive, locally delivered chlorhexidine on patients with chronic periodontitis. | |
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MedLine Citation:
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PMID: 20593635 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The impact of a locally delivered chlorhexidine chip (Periochip) on clinical and microbiological parameters of chronic periodontitis requires further documentation. The aim of the present study was to investigate the effects of the chip as an adjunct to mechanical treatment of chronic periodontitis. METHODS: Fifty patients with chronic periodontitis were randomized into two groups. The test group (n = 25) received scaling and root planing and adjunctive Periochip in four pockets. The control group (n = 25) received scaling and root planing only. Clinical indices (probing depth, probing attachment level, bleeding on probing) were assessed at baseline, three and six months. Subgingival samples were analyzed at baseline, three weeks, three and six months after treatment for levels of eight bacterial species using "checkerboard" DNA-DNA hybridization. RESULTS: The targeted difference of probing depth of 2 mm between groups was not observed. Both treatments resulted in improvement of clinical indices and non-statistically significant differences were observed between the two groups at any time point, with the exception of bleeding on probing at three months (ANOVA, p < 0.05). No major differences were observed concerning levels of important periodontal pathogens (Mann-Whitney test, p < or = 0.05). CONCLUSIONS: In this small, six-month, phase 4 trial, no differences in mean probing depth reduction or "red-complex" periodontal pathogens were detected for patients with chronic periodontitis treated with adjunctive chlorhexidine chip (single administration) as compared to patients treated with scaling and root planing alone. |
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Authors:
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Dimitra Sakellari; Sakellari Dimitra; Ioannis Ioannidis; Ioannidis Ioannis; Malama Antoniadou; Antoniadou Malama; Theodora Slini; Slini Theodora; Antonis Konstantinidis; Konstantinidis Antonis |
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Publication Detail:
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Type: Clinical Trial, Phase IV; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the International Academy of Periodontology Volume: 12 ISSN: 1466-2094 ISO Abbreviation: J Int Acad Periodontol Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-07-02 Completed Date: 2010-07-29 Revised Date: 2010-07-30 |
Medline Journal Info:
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Nlm Unique ID: 100888553 Medline TA: J Int Acad Periodontol Country: England |
Other Details:
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Languages: eng Pagination: 20-6 Citation Subset: D |
Affiliation:
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Department of Preventive Dentistry, Periodontology and Implant Biology, Aristotle University of Thessaloniki, Greece. dimisak@med.auth.gr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Analysis of Variance Anti-Infective Agents, Local / administration & dosage* Chlorhexidine / administration & dosage* Chronic Periodontitis / drug therapy*, microbiology Combined Modality Therapy DNA, Bacterial / analysis Dental Plaque / drug therapy, microbiology Dental Scaling Drug Delivery Systems Female Gram-Negative Anaerobic Bacteria / drug effects*, genetics Humans Longitudinal Studies Male Middle Aged Periodontal Index Periodontal Pocket / drug therapy*, microbiology Severity of Illness Index Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents, Local; 0/DNA, Bacterial; 55-56-1/Chlorhexidine |
| Comments/Corrections | |
Erratum In:
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J Int Acad Periodontol. 2010 Apr;12(2):62 Note: Dimitra, Sakellari [corrected to Sakellari, Dimitra]; Ioannis, Ioannidis [corrected to Ioannidis, Ioannis]; Malama, Antoniadou [corrected to Antoniadou, Malama]; Theodora, Slini [corrected to Slini, Theodora]; Antonis, Konstantinidis [corrected to Konstantinidis, Antonis] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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