Document Detail

Clinical and microbiological characteristics of bloodstream infections in a tertiary hospital in Maceió, Alagoas, Brazil.
MedLine Citation:
PMID:  20563445     Owner:  NLM     Status:  MEDLINE    
We observed the clinical and microbiological characteristics of several stages of bloodstream infections (BSI), as well as the mortality attributed to it in a tertiary hospital in the northeast of Brazil (in the city of Maceió, Alagoas). A prospective cohort of 143 patients who had at least one positive blood culture was enrolled in the study. Their clinical evolution was followed up for 30 days from October 2005 to December 2006. The relation among the qualitative variables was verified through Chi-square test. The significance level was 5%. The statistical package adopted was SPSS 15.0 for Windows. Up to the thirtieth day, 30.1% of the patients presented bacteremia and 69.9% developed sepsis. Among these, 20.3% developed severe sepsis and 10.5% septic shock. The mortality attributed to it was 37.8%. In bacteremia, sepsis, severe sepsis, and septic shock conditions, mortality rates were 9.3%, 50%, 65.5%, and 84.6%, respectively. Respiratory (32.2%) and urinary (14%) sources and the ones related to central venous catheter (14%) were prevalent. In the wards 55.12% of the cases developed sepsis, whereas in the intensive care units, the rate was 87.69% (p < 0.05). Chronic renal failure, diabetes mellitus, and neuropathy were present in 21.7%, 26.6%, and 29.4% of the cases, respectively. Coagulase-negative Staphylococcus (25.9%), Staphylococcus aureus (21%), and Klebsiella pneumoniae (14%) were the most present microorganism in the sample. The high morbidity and mortality rates in this study are attributed to the lack of knowledge on BSI characteristics and on instituted protocols for detection and treatment in early stages.
Maria Tereza Freitas Tenório; Zenaldo Porfírio; Antonio Carlos Lopes; Sonia Cendon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases     Volume:  14     ISSN:  1678-4391     ISO Abbreviation:  Braz J Infect Dis     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-06-21     Completed Date:  2010-09-20     Revised Date:  2011-10-03    
Medline Journal Info:
Nlm Unique ID:  9812937     Medline TA:  Braz J Infect Dis     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  175-9     Citation Subset:  IM    
Universidade Federal de São Paulo, São Paulo, Brazil.
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MeSH Terms
Brazil / epidemiology
Gram-Negative Bacteria / isolation & purification*
Gram-Positive Bacteria / isolation & purification*
Middle Aged
Prospective Studies
Sepsis / microbiology*,  mortality
Severity of Illness Index

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