| Clinical, metabolic, and endocrine parameters in response to metformin and lifestyle intervention in women with polycystic ovary syndrome: a randomized, double-blind, and placebo control trial. | |
| | |
MedLine Citation:
|
PMID: 20148739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of this study was to evaluate the effects of metformin in addition to diet and exercise on endocrine and metabolic disturbances in women with polycystic ovary syndrome (PCOS) in a prospective, double-blind, randomized, placebo (PBO) control trial. Thirty women with insulin resistance and PCOS received lifestyle modification and 1500 mg of metformin or placebo for 4 months. Before and after treatment, body mass index, waist/hip ratio, blood pressure, hirsutism, and menstrual patterns were evaluated. Serum concentrations of gonadotropins, androgens, progesterone, glucose, insulin, and lipids were measured. Lifestyle interventions resulted in similar weight and menstrual cycle's improvements in both groups. A significant reduction in serum fasting insulin, HOMA index, waist and testosterone levels was only observed with metformin. There were no significant changes in androstenedione, dehydroepiandrosterone sulfate, gonadotropins, and lipids levels. No other changes were observed in hirsutism or blood pressure. These findings suggest that metformin has an additive effect to diet and exercise to improve parameters of hyperandrogenism and insulin resistance. Although, a small decrease in body weight trough lifestyle changes could be enough to improve menstrual cycles in insulin-resistant women with PCOS. |
| | |
Authors:
|
Carolina Fux Otta; Myriam Wior; Gabriel S Iraci; Raquel Kaplan; Diana Torres; María Isabel Gaido; Eduardo P Wyse |
Related Documents
:
|
11716159 - Premature adrenarche. 2642919 - Insulin administration alters gonadal steroid metabolism independent of changes in gona... 2679969 - Monoaminergic activity at the level of the hypothalamus and striatum: relationship to a... 19298279 - Is there a role for insulin resistance in nonobese patients with idiopathic hirsutism? 11511859 - Polycystic ovary syndrome and insulin-resistant hyperinsulinemia. 12151419 - Should patients with polycystic ovarian syndrome be treated with metformin?: an enthusi... 16888159 - The glucagon-miniglucagon interplay: a new level in the metabolic regulation. 2968889 - District diabetes centres in the united kingdom. a report on a workshop held by the dia... 18156459 - A differential diagnostic model of diabetic nephropathy and non-diabetic renal diseases. |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: 26 ISSN: 1473-0766 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-02-12 Completed Date: 2010-10-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: England |
Other Details:
|
Languages: eng Pagination: 173-8 Citation Subset: IM |
Affiliation:
|
Departamento de Endocrinología, Centro Médico de Córdoba, Hospital Privado, Córdoba Capital, Argentina. endofux@yahoo.com.ar |
| Data Bank Information | |
Bank Name/Acc. No.:
|
ClinicalTrials.gov/NCT00679679 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Pressure / physiology Body Mass Index Cholesterol / blood Double-Blind Method Female Follicle Stimulating Hormone / blood Hirsutism / physiopathology Humans Hypoglycemic Agents / administration & dosage* Insulin Resistance / physiology Life Style* Luteinizing Hormone / blood Menstrual Cycle / physiology Metformin / administration & dosage* Polycystic Ovary Syndrome / blood, drug therapy, physiopathology, therapy* Statistics, Nonparametric Testosterone / blood Triglycerides / blood Waist-Hip Ratio Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Hypoglycemic Agents; 0/Triglycerides; 57-88-5/Cholesterol; 58-22-0/Testosterone; 657-24-9/Metformin; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Serum resistin and adiponectin levels in young non-obese women with polycystic ovary syndrome.
Next Document: Effect of coasting on IVF cycle characteristics and outcome in short vs. long GnRH agonist protocols...