Document Detail

Clinical and metabolic consequences to cattle of rumen overdosing with di-ureido iso-butane (DUIB).
MedLine Citation:
PMID:  24244     Owner:  NLM     Status:  MEDLINE    
Di-ureido iso-butane (DUIB) was overdosed on three occasions to two year-old bullocks, under experimental conditions. Six g/kg live weight of DUIB was mixed manually into the rumen contents formed by a predominantly hay diet (10 kg) with added concentrates (2 kg). Marked clinical signs were observed for 72 h before recovery. Food and water intake were interrupted and a smell of ammonia saturated the accommodation. Blood concentrations of urea-nitrogen increased, while glucose fell; a metabolic alkalosis was present. Rumen VFA concentrations fell, but without altering the proportions of the individual acids present, pH increased, urea-nitrogen and ammonia-nitrogen concentrations fluctuated markedly. The pH of duodenal contents increased. Clinical recovery appeared complete after six days with biochemical homeostasis nearly restored.
P A Mullen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research in veterinary science     Volume:  24     ISSN:  0034-5288     ISO Abbreviation:  Res. Vet. Sci.     Publication Date:  1978 Jan 
Date Detail:
Created Date:  1978-04-17     Completed Date:  1978-04-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0401300     Medline TA:  Res Vet Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  8-13     Citation Subset:  IM    
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MeSH Terms
Ammonia / metabolism
Cattle / metabolism*
Duodenum / metabolism
Hydrogen-Ion Concentration
Osmolar Concentration
Rumen / metabolism*
Urea / analogs & derivatives*,  metabolism
Reg. No./Substance:
57-13-6/Urea; 7664-41-7/Ammonia

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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