Document Detail

Clinical manifestations of familial medullary thyroid carcinoma.
MedLine Citation:
PMID:  15271414     Owner:  NLM     Status:  MEDLINE    
We conducted a large-scale nation-wide questionnaire survey to ascertain the status of familial medullary thyroid carcinoma (MTC) in Japan in 2002. Out of a total of 271 MTC cases (male to female ratio 1:1.4), multiple endocrine neoplasia (MEN) 2A accounted for 83 cases (30.6%), familial MTC (FMTC) for 14 cases (5.1%), MEN for 11 cases (4.1%), and sporadic MTC for 163 cases (60.1%). Mean age at the time of diagnosis was 35.6 in MEN2A, 34.6 in FMTC, 30.5 in MEN2B, and 47.6 in sporadic MTC. Forty-five percent of MEN2A patients had pheochromocytoma and 11% of MEN2A patients had parathyroid disorders when MTC was diagnosed. Finally, the RET oncogene test yielded the largest number of initial findings that led to diagnosis of familial MTC.
Kaori Kameyama; Hiroko Okinaga; Hiroshi Takami
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie     Volume:  58     ISSN:  0753-3322     ISO Abbreviation:  Biomed. Pharmacother.     Publication Date:    2004 Jul-Aug
Date Detail:
Created Date:  2004-07-23     Completed Date:  2005-01-18     Revised Date:  2012-06-04    
Medline Journal Info:
Nlm Unique ID:  8213295     Medline TA:  Biomed Pharmacother     Country:  France    
Other Details:
Languages:  eng     Pagination:  348-50     Citation Subset:  IM    
Division of Diagnostic Pathology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
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MeSH Terms
Adrenal Gland Neoplasms / epidemiology,  genetics
Carcinoma, Medullary / epidemiology*,  genetics*
Middle Aged
Multiple Endocrine Neoplasia Type 2a / epidemiology,  genetics
Multiple Endocrine Neoplasia Type 2b / epidemiology,  genetics
Oncogene Proteins / genetics
Parathyroid Diseases / epidemiology,  genetics
Pheochromocytoma / epidemiology,  genetics
Proto-Oncogene Proteins c-ret
Receptor Protein-Tyrosine Kinases / genetics
Thyroid Neoplasms / epidemiology*,  genetics*
Reg. No./Substance:
0/Oncogene Proteins; EC Proteins c-ret; EC protein, human; EC Protein-Tyrosine Kinases

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