| Clinical manifestations of familial medullary thyroid carcinoma. | |
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MedLine Citation:
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PMID: 15271414 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We conducted a large-scale nation-wide questionnaire survey to ascertain the status of familial medullary thyroid carcinoma (MTC) in Japan in 2002. Out of a total of 271 MTC cases (male to female ratio 1:1.4), multiple endocrine neoplasia (MEN) 2A accounted for 83 cases (30.6%), familial MTC (FMTC) for 14 cases (5.1%), MEN for 11 cases (4.1%), and sporadic MTC for 163 cases (60.1%). Mean age at the time of diagnosis was 35.6 in MEN2A, 34.6 in FMTC, 30.5 in MEN2B, and 47.6 in sporadic MTC. Forty-five percent of MEN2A patients had pheochromocytoma and 11% of MEN2A patients had parathyroid disorders when MTC was diagnosed. Finally, the RET oncogene test yielded the largest number of initial findings that led to diagnosis of familial MTC. |
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Authors:
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Kaori Kameyama; Hiroko Okinaga; Hiroshi Takami |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie Volume: 58 ISSN: 0753-3322 ISO Abbreviation: Biomed. Pharmacother. Publication Date: 2004 Jul-Aug |
Date Detail:
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Created Date: 2004-07-23 Completed Date: 2005-01-18 Revised Date: 2012-06-04 |
Medline Journal Info:
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Nlm Unique ID: 8213295 Medline TA: Biomed Pharmacother Country: France |
Other Details:
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Languages: eng Pagination: 348-50 Citation Subset: IM |
Affiliation:
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Division of Diagnostic Pathology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. kameyama@sc.itc.keio.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Gland Neoplasms
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epidemiology,
genetics Adult Carcinoma, Medullary / epidemiology*, genetics* Female Humans Japan Male Middle Aged Multiple Endocrine Neoplasia Type 2a / epidemiology, genetics Multiple Endocrine Neoplasia Type 2b / epidemiology, genetics Oncogene Proteins / genetics Parathyroid Diseases / epidemiology, genetics Pheochromocytoma / epidemiology, genetics Proto-Oncogene Proteins c-ret Proto-Oncogenes Receptor Protein-Tyrosine Kinases / genetics Thyroid Neoplasms / epidemiology*, genetics* |
| Chemical | |
Reg. No./Substance:
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0/Oncogene Proteins; EC 2.7.10.1/Proto-Oncogene Proteins c-ret; EC 2.7.10.1/RET protein, human; EC 2.7.10.1/Receptor Protein-Tyrosine Kinases |
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