Document Detail

Clinical manifestations and characteristics of patients with acute generalized exanthematous pustulosis in Asia.
MedLine Citation:
PMID:  18709306     Owner:  NLM     Status:  MEDLINE    
Acute generalized exanthematous pustulosis is a rare, sterile inflammation of the skin (and mucous membranes) characterized by acute onset of generalized pustule formation, fever and leukocytosis, and a rapid resolution. A computer-based search of the literature revealed only a limited series of reports, none of them based on Asian patients. We identified and retrospectively analysed 16 biopsy-proven and criteria-matched patients over a 15-year period in a single medical centre. The study showed a female predominance (11 of 16 patients), a relatively low association with systemic drugs (62.5% vs. 87% in a previous report) and normal renal function (in contrast to a previous report where 32% of patients had renal failure). The study also revealed high levels of C-reactive protein (76.0 mg/l) and normal absolute eosinophil count (176.2/microl) in most patients. Furthermore, there was no difference between different treatment regimens regard-ing the course and duration of the disease or the length of fever (p>0.05). In addition, if the patients were subdivided by aetiology into those strongly associated with or not strongly associated with systemic drugs, a significant difference was found in age of onset between the 2 groups (p<0.01).
Shyue-Luen Chang; Yu-Huei Huang; Chih-Hsun Yang; Sindy Hu; Hong-Shang Hong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  88     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-08-18     Completed Date:  2008-11-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  363-5     Citation Subset:  IM    
Department of Dermatology, Chang-Gung Memorial Hospital and Chang-Gung University College of Medicine, Taipei, Taiwan.
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MeSH Terms
Acute Disease
Age of Onset
C-Reactive Protein / analysis
Child, Preschool
Eosinophils / cytology
Exanthema* / chemically induced,  drug therapy,  epidemiology,  physiopathology
Kidney / physiopathology
Leukocyte Count
Middle Aged
Retrospective Studies
Sex Factors
Skin Diseases, Vesiculobullous* / chemically induced,  drug therapy,  epidemiology,  physiopathology
Taiwan / epidemiology
Reg. No./Substance:
9007-41-4/C-Reactive Protein

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