Document Detail

Clinical manifestations associated with Kawasaki disease shock syndrome in Mexican children.
MedLine Citation:
PMID:  23152158     Owner:  NLM     Status:  Publisher    
Recently, there have been increasing reports of severe forms of Kawasaki disease (KD) associated with shock that have been managed in pediatric intensive care units. It has been suggested that KD is more severe in the Hispanic population. We conducted a study to determine the frequency of Kawasaki disease shock syndrome (KDSS) in our population and compared characteristics between patients with KD without shock and patients with KDSS. Data from 214 patients with KD treated in a tertiary pediatric hospital were collected during a 12-year period. We compared clinical and laboratory features of KD patients without shock and KDSS patients. Of 214 consecutive patients with KD, 11 (5 %) met the definition for KDSS. All of these patients received fluid resuscitation, seven (64 %) required inotropic treatment, and six (54 %), ventilatory support. On admission, seven of these patients (64 %) had an incomplete presentation of the disease, whereas in the group of patients without shock, the relative frequency of an incomplete presentation was 29 %. Twenty percent (3/11) of patients with KDSS presented giant coronary aneurysms versus none of 203 KD patients without shock (p = 0.001); myocardial infarction, 27 % (3/11), versus 1 % (2/203) (p = 0.001); and intravenous immunoglobulin (IVIG) resistance, 60 % (6/11), versus 12 % (24/203). Gastrointestinal manifestations in the acute phase occurred in 91 % of KDSS patients versus 30 % patients without shock (p = 0.001). Conclusion. Patients with KD presenting in shock seem to have an increase in gastrointestinal manifestations, incomplete presentation, IVIG resistance, and worse cardiac outcomes. Larger, prospective, multicentre studies should be carried out to corroborate these findings.
Luisa Berenise Gámez-González; Chiharu Murata; Mireya Muñoz-Ramírez; Marco Yamazaki-Nakashimada
Related Documents :
16627228 - Chronic pouchitis after ileal pouch-anal anastomosis for ulcerative colitis: effect on ...
10855348 - Feasibility of quality-of-life research on the internet: a follow-up study.
15108758 - Opioid use and health care charges at the end of life in patients with metastatic cancer.
24359718 - Looking for lithotripsy: accessibility and portability of canadian healthcare.
12396858 - A feasibility study of remote monitoring of asthmatic patients.
20234008 - Treatment preparatory to psychoanalysis: a reconsideration after twenty-five years.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-15
Journal Detail:
Title:  European journal of pediatrics     Volume:  -     ISSN:  1432-1076     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Servicio de Inmunología Clínica, Instituto Nacional de Pediatría, Insurgentes Sur 3700-C Col. Insurgentes Cuicuilco, Mexico D.F., Mexico.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparative functional cell biological analysis of mesenchymal stem cells of the head and neck regio...
Next Document:  Endothelial microparticle release is stimulated in vitro by purified IgG from patients with the an...