Document Detail


Clinical manifestation of prenatal exposure to valproic acid using case reports and epidemiologic information.
MedLine Citation:
PMID:  2248297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study includes 28 patients prenatally exposed to valproic acid (VPA) monitored by the Spanish Collaborative Study of Congenital Malformations (ECEMC), from April 1976 to December 1988. Among the 28 cases, 15 (53.6%) were exposed only to VPA and 13 (46.4%) to VPA plus other anticonvulsant drugs. The clinical manifestations observed in those prenatally exposed only to VPA, are compared with the abnormalities observed in those with prenatal exposure to VPA plus other anticonvulsant drugs. To better define the spectrum of clinical manifestation of the prenatal exposure to VPA we used, besides our clinical observations and those from the literature, all available epidemiological data. We consider that a "valproate embryofetopathy (VPEF)" could exist, because different anomalies have been observed in children prenatally exposed to VPA in monotherapy. A facial phenotype of VPA exposure has been reported, and epidemiologic studies have shown an increased risk for congenital defects. However, from a review of published cases as well as those in the present study, it appears that the spectrum of VAE in monotherapy may not include oral clefts.
Authors:
M L Martínez-Frías
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  American journal of medical genetics     Volume:  37     ISSN:  0148-7299     ISO Abbreviation:  Am. J. Med. Genet.     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1991-01-10     Completed Date:  1991-01-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708900     Medline TA:  Am J Med Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  277-82     Citation Subset:  IM    
Affiliation:
Estudio Colaborativo Español de Malformaciones Congénitas, INSALUD, Facultad de Medicina, Hospital Universitario San Carlos, Universidad Complutense de Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced*
Anticonvulsants / adverse effects
Case-Control Studies
Face / abnormalities
Female
Humans
Infant, Newborn
Male
Phenotype
Pregnancy
Valproic Acid / adverse effects*
Chemical
Reg. No./Substance:
0/Anticonvulsants; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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