Document Detail


Clinical manifestation of gadodiamide-related nephrogenic systemic fibrosis.
MedLine Citation:
PMID:  18397714     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: To further characterize the clinical signs and symptoms of nephrogenic systemic fibrosis, a new and serious disease affecting renal failure patients and caused by some Gd-containing contrast agents, including gadodiamide. MATERIAL: 22 cases of gadodiamide-related nephrogenic systemic fibrosis followed at the nephrology department of Copenhagen University Hospital Herlev. METHOD: Retrospective cohort study based on medical records, personal interviews and physical examinations. RESULTS: Typical first signs of the disease were skin discoloration, induration and warmth, itching, constant pain and other neuropathic symptoms localized to the lower legs. First sign appeared in a median of 14 days (range 0 â 53 days) after gadodiamide exposure. Associated early symptoms included sleeplessness and transient, diffuse hair loss. The predominant late symptom was symmetrical skin stiffness of extremities with or without restricted joint motion. Ten of 22 patients (45, 95% CI: 27 â 66%) were severely disabled due to contractures on the average of 29 months after being exposed to gadodiamide. Four patients died (18, 95% CI: 6 â 41). Patients perceived that intensive physiotherapy was effective in limiting disabling contractures. CONCLUSIONS: Signs and symptoms of nephrogenic systemic fibrosis vary over time and between patients. The disease leads to severe disability in a significant proportion of affected patients. Intensive physiotherapy may limit the development of contractures.
Authors:
P Marckmann; L Skov; K Rossen; H S Thomsen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical nephrology     Volume:  69     ISSN:  0301-0430     ISO Abbreviation:  Clin. Nephrol.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-04-09     Completed Date:  2008-06-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0364441     Medline TA:  Clin Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  161-8     Citation Subset:  IM    
Affiliation:
Department of Nephrology, Copenhagen University Hospital Herlev, Denmark. peter.marckmann@dadlnet.dk
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Contrast Media / administration & dosage,  adverse effects*
Female
Fibrosis / chemically induced
Follow-Up Studies
Gadolinium DTPA / administration & dosage,  adverse effects*,  diagnostic use
Glomerular Filtration Rate / drug effects
Humans
Injections, Intravenous
Kidney Failure, Chronic / chemically induced,  pathology*,  physiopathology
Male
Middle Aged
Prognosis
Retrospective Studies
Severity of Illness Index
Syndrome
Chemical
Reg. No./Substance:
0/Contrast Media; 122795-43-1/gadodiamide; 80529-93-7/Gadolinium DTPA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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