Document Detail

Clinical management of renal cell carcinoma with venous tumor thrombus.
MedLine Citation:
PMID:  24752606     Owner:  NLM     Status:  Publisher    
OBJECTIVES: Venous invasion is common in advanced renal cell carcinoma (RCC) due to the unique biology of this cancer. The presence of a tumor thrombus often makes clinical management challenging. In this review, we detail specific preoperative, perioperative, and surgical strategies involving the care of the complex kidney cancer patient with venous tumor involvement.
METHODS: We performed a comprehensive review of selected peer-reviewed publications regarding RCC tumor thrombus biology, medical and surgical management techniques, and immediate and long-term outcomes.
RESULTS: The perioperative management may require special imaging techniques, preoperative testing, very recent imaging, and consultation with other surgical services. There are various approaches to these patients as the clinical presentation, stage of disease, primary tumor size, level of thrombus, degree of venous occlusion, presence of bland thrombus, and primary tumor laterality influence management. Select patients with metastatic disease can do well with cytoreductive nephrectomy and thrombectomy. Those with localized disease have a high risk of recurrence; however, some patients can exhibit durable survival with surgery alone. The evolving surgical and medical treatments are discussed.
CONCLUSIONS: Even when these surgeries are performed in high volume centers, significant perioperative complications are common and greater complications are seen with higher thrombus extent. If surgery is attempted, it is important for urologic oncologists to follow strict attention to specific surgical principles. These general principles include complete vascular control, avoidance of thrombus embolization, close hemodynamic monitoring, and institutional resources for caval resection/replacement and venous bypass if necessary.
Nnenaya Agochukwu; Brian Shuch
Related Documents :
1844036 - Repair of unilateral and bilateral cleft noses--an experience of 103 cases.
25077636 - Thoracoscopic part of minimal invasive oesophagectomy in semiprone position: our initia...
24681166 - Barbed suture versus traditional suture in single-port total laparoscopic hysterectomy.
24891776 - Inguinal hernia repair via application of mesh in front of and behind the fascia transv...
8799536 - Extended anterior cervical discectomy without fusion: a simple and sufficient operation...
11167876 - A normal appendix found during diagnostic laparoscopy should not be removed.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-22
Journal Detail:
Title:  World journal of urology     Volume:  -     ISSN:  1433-8726     ISO Abbreviation:  World J Urol     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307716     Medline TA:  World J Urol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  E50K-OPTN-Induced Retinal Cell Death Involves the Rab GTPase-Activating Protein, TBC1D17 Mediated Bl...
Next Document:  Do we need the nerve sparing radical prostatectomy techniques (intrafascial vs. interfascial) in men...