Document Detail


Clinical management of patients with systemic lupus erythematosus (SLE) with different C1q-CIC and C3 concentrations.
MedLine Citation:
PMID:  20514769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Over the third of SLE (Systemic Lupus Erythematosus) patients have a high level auto-antibodies-antigen complex that contains some complement proteins, especially C1q as the trigger protein in the classical complement activation pathway. So, the SLE, as an autoimmune disease, is certainly related to disorders caused by activation of complement system, that finally leads to tissue damage. It may also be caused by hereditary deficiency (complement genes mutations). In such case, some components of the complement system might be inactivated. There are mutations that cause disorders in each of three complement system activation pathways (classical, alternative and lectin).The serum samples of SLE patients show the presence of specific autoantibodies for some complement components. Today, for clinical management of SLE patients, determination of level of C1q-CIC and C3 complement component in serum specimens have great diagnostic and therapeutic importance. During the year 2000, we analyzed a numerous serum samples from patients suspected to autoimmune diseases (SLE especially). The samples were collected from several clinics in the Clinical Center of University of Sarajevo, mostly from Clinic of Infectious Diseases, Pediatrics, Internal Medicine and Gastroenterohepatology Clinic. Primary samples went through screening for the presence of ANA using ANA-IFA method and further characterization of ANA positive samples was carried out using IFA-ANA titration, ELISA and nephelometry.
Authors:
Jasenko Karamehic; Djemo Subasic; Mersija Kasumovic; Harun Hodzic; Lamija Prljaca-Zecevici; Mersiha Tufekcic; Izeta Aganovic-Musinovic
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medicinski arhiv     Volume:  64     ISSN:  0350-199X     ISO Abbreviation:  Med Arh     Publication Date:  2010  
Date Detail:
Created Date:  2010-06-02     Completed Date:  2010-07-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400722     Medline TA:  Med Arh     Country:  Bosnia and Hercegovina    
Other Details:
Languages:  eng     Pagination:  75-9     Citation Subset:  IM    
Affiliation:
Institute of Clinical immunology-Clinical Centre, University of Sarajevo, Bolnicka 25, 71000 Sarajevo, Bosnia and Herzegovina.
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MeSH Terms
Descriptor/Qualifier:
Antigen-Antibody Complex / blood*
Autoantibodies / blood
Complement C1q / analysis*
Complement C3 / analysis*
Fluorescent Antibody Technique
Humans
Lupus Erythematosus, Systemic / immunology*,  therapy
Chemical
Reg. No./Substance:
0/Antigen-Antibody Complex; 0/Autoantibodies; 0/Complement C3; 80295-33-6/Complement C1q

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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