Document Detail

Clinical management of clozapine patients in relation to efficacy and side-effects.
MedLine Citation:
PMID:  1358128     Owner:  NLM     Status:  MEDLINE    
Medical charts of 480 schizophrenic in-patients (581 treatments) were analysed to evaluate the efficacy and side-effects of clozapine. Clozapine treatment lasted for mean 49 (s.d. 38) days. Of the sample, 11.0% showed worsening or no change, 31.5% slight improvement, 53.0% marked improvement and 4.5% almost total reduction of symptoms. At least one major side-effect occurred in 68.0% of patients. A combination of clozapine with classical neuroleptics, antidepressants, benzodiazepines or lithium is tolerated by most patients, but increases the incidence of some side-effects. Clozapine treatment had to be discontinued because of severe side-effects in 8.6% of patients. In 81 schizophrenic out-patients, clozapine significantly reduced the days of in-patient treatment and number of hospital readmissions. Two patients developed leucopenia but had no complications after clozapine withdrawal. This study indicates a satisfactory benefit/risk ratio and compliance in most of the patients.
D Naber; R Holzbach; C Perro; H Hippius
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The British journal of psychiatry. Supplement     Volume:  -     ISSN:  0960-5371     ISO Abbreviation:  Br J Psychiatry Suppl     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-12-02     Completed Date:  1992-12-02     Revised Date:  2008-02-22    
Medline Journal Info:
Nlm Unique ID:  9001294     Medline TA:  Br J Psychiatry Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  54-9     Citation Subset:  IM    
Psychiatric Hospital, University of Munich, Germany.
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MeSH Terms
Antipsychotic Agents / therapeutic use
Clozapine / administration & dosage,  adverse effects,  therapeutic use*
Drug Therapy, Combination
Middle Aged
Patient Compliance
Schizophrenia / diagnosis,  drug therapy*
Schizophrenic Psychology
Reg. No./Substance:
0/Antipsychotic Agents; 5786-21-0/Clozapine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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