Document Detail

Clinical management of adult ITP prior to splenectomy: a perspective.
MedLine Citation:
PMID:  11913995     Owner:  NLM     Status:  MEDLINE    
A philosophy of management of adult immune thrombocytopenic purpura (ITP) prior to splenectomy is presented. The initial action is to determine whether the condition is hyperacute, acute, or chronic. In symptomatic cases, initial remission usually requires steroids and the administration of intravenous immunoglobulin (i.v.Ig), followed by platelet transfusion if the patient is actively hemorrhaging. Once initial remission is achieved, a rapid reduction to minimal maintenance therapy should be made. The options include steroids, immunotherapy, and chemotherapy. Adjustments to maintenance therapy must be made with the understanding that response rates vary for each agent.
W F Rosse
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Blood reviews     Volume:  16     ISSN:  0268-960X     ISO Abbreviation:  Blood Rev.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-26     Completed Date:  2002-08-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8708558     Medline TA:  Blood Rev     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  47-9     Citation Subset:  IM    
Copyright Information:
Copyright 2002, Elsevier Science Ltd. All rights reserved.
Division of Hematology, Department of Medicine, Duke University Medical Center, Durham, NC 27707, USA.
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MeSH Terms
Disease Management
Perioperative Care
Purpura, Thrombocytopenic, Idiopathic / complications,  surgery*,  therapy
Remission Induction / methods
Splenectomy / methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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